Asha Shekaran

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BACKGROUND AIMS Human mesenchymal stromal cells or marrow stromal cells (MSCs) are of great interest for bone healing due to their multi-potency and trophic effects. However, traditional MSC expansion methods using 2-dimensional monolayer (MNL) flasks or cell stacks are limited by labor-intensive handling, lack of scalability, the need for enzymatic cell(More)
BACKGROUND Mesenchymal stem cells (MSCs) are of great interest in bone regenerative medicine due to their osteogenic potential and trophic effects. However, challenges to large-scale production of MSCs can hinder the translation of MSC therapies. 3D Microcarrier (MC)-based MSC culture presents a scalable and cost-effective alternative to conventional(More)
Tissue engineered vascular grafts may one day provide a solution to many of the limitations associated with the use of synthetic vascular grafts and vein autografts. In order for vascular tissue engineering to become a clinical reality, scaffolds and cell sources that meet rigorous scientific as well as social criteria will be required. Several laboratories(More)
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