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Clinical experience with preimplantation diagnosis of sex by dual fluorescent in situ hybridization
PurposeOur purpose was to assess the clinical application of dual fluorescent in situhybridization (FISH) for the diagnosis of sex in the human preimplantation embryo.ResultsOver a 2-year period, 18Expand
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NLRP7 and KHDC3L, the two maternal-effect proteins responsible for recurrent hydatidiform moles, co-localize to the oocyte cytoskeleton.
STUDY QUESTION What is the subcellular localization in human oocytes and preimplantation embryos, of the two maternal-effect proteins, NLRP7 and KHDC3L, responsible for recurrent hydatidiform molesExpand
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Report of four new patients with protein-truncating mutations in C6orf221/KHDC3L and colocalization with NLRP7
To date, two maternal-effect genes have been shown to have causative roles in recurrent hydatidiform moles (RHMs); NLRP7 that is mutated in 48–60% of patients with RHMs and C6orf221 (HUGO-approvedExpand
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Vascular endothelial growth factor A and its two receptors in human preantral follicles from fetuses, girls, and women.
OBJECTIVE To investigate the expression of vascular endothelial growth factor A (VEGF-A) and that its two receptors (VEGFR1, VEGFR2) in human preantral follicles. DESIGN Immunohistochemical, inExpand
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Transmission ratio distortion in the myotonic dystrophy locus in human preimplantation embryos
One form of myotonic dystrophy, dystrophia myotonica 1 (DM1), is caused by the expansion of a (CTG)n repeat within the dystrophia myotonica-protein kinase (DMPK) gene located in chromosome regionExpand
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Expression of growth-differentiating factor 9 and its type 1 receptor in human ovaries.
The expression of growth-differentiating factor 9 (GDF9) has not been studied in ovaries from girls and human fetuses nor has its receptor transforming growth factor-beta1 receptor (TGFbetaR1) beenExpand
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Fibroblast growth factor 10 in human ovaries.
The expression of fibroblast growth factor 10 (FGF-10) has not been studied in human ovarian cortical follicles. The aim of the present study was to investigate the expression of FGF-10 in preantralExpand
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Expression of basic fibroblast growth factor and its receptors in human ovarian follicles from adults and fetuses.
OBJECTIVE To investigate the immunocytochemical expression and presence of mRNA transcripts for basic fibroblast growth factor (bFGF) and its four receptors (FGFR-1, -2, -3, and -4) in ovaries fromExpand
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Comprehensive analysis of 204 sporadic hydatidiform moles: revisiting risk factors and their correlations with the molar genotypes
Hydatidiform mole (HM) is an aberrant human pregnancy characterized by excessive trophoblastic proliferation and abnormal embryonic development. HM has two morphological types, complete (CHM) andExpand
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