BACKGROUND Multiple genetic factors and their interactive effects are speculated to contribute to complex diseases. Detecting such genetic interactive effects, i.e., epistatic interactions, however, remains a significant challenge in large-scale association studies. RESULTS We have developed a new method, named SNPInterForest, for identifying epistatic… (More)
To discover susceptibility genes of late-onset Alzheimer's disease (LOAD), we conducted a 3-stage genome-wide association study (GWAS) using three populations: Japanese from the Japanese Genetic Consortium for Alzheimer Disease (JGSCAD), Koreans, and Caucasians from the Alzheimer Disease Genetic Consortium (ADGC). In Stage 1, we evaluated data for 5,877,918… (More)
Hepatitis B virus (HBV) infection can lead to serious liver diseases, including liver cirrhosis (LC) and hepatocellular carcinoma (HCC); however, about 85-90% of infected individuals become inactive carriers with sustained biochemical remission and very low risk of LC or HCC. To identify host genetic factors contributing to HBV clearance, we conducted… (More)
Rapid advances in the biomedical field have resulted in the accumulation of numerous experimental results, mainly in text form. To extract knowledge from biomedical papers, or use the information they contain to interpret experimental results, requires improved techniques for retrieving information from the biomedical literature. In many cases, since the… (More)
BACKGROUND With improvements in genotyping technologies, genome-wide association studies with hundreds of thousands of SNPs allow the identification of candidate genetic loci for multifactorial diseases in different populations. However, genotyping errors caused by genotyping platforms or genotype calling algorithms may lead to inflation of false… (More)
There are errors in Tables 2 and S2. Please see the corrected tables below. Copyright: © 2015 Awata et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
MOTIVATION With the rapid advancement of biomedical science and the development of high-throughput analysis methods, the extraction of various types of information from biomedical text has become critical. Since automatic functional annotations of genes are quite useful for interpreting large amounts of high-throughput data efficiently, the demand for… (More)
Predicting the interactions between all the possible pairs of proteins in a given organism (making a protein-protein interaction map) is a crucial subject in bioinformatics. Most of the previous methods based on supervised machine learning use datasets containing approximately the same number of interacting pairs of proteins (positives) and non-interacting… (More)