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The evolutionarily conserved peripheral benzodiazepine receptor (PBR), or 18-kDa translocator protein (TSPO), is thought to be essential for cholesterol transport and steroidogenesis, and thus life. TSPO has been proposed as a biomarker of neuroinflammation and a new drug target in neurological diseases ranging from Alzheimer's disease to anxiety. Here we(More)
In PET imaging, research groups have recently proposed different experimental set ups allowing multiple animals to be simultaneously imaged in a scanner in order to reduce the costs and increase the throughput. In those studies, the technical feasibility was demonstrated and the signal degradation caused by additional mice in the FOV characterized, however,(More)
The X-ray spectra of Low Mass X-ray Binaries (LMXB) can change on short timescales , making it difficult to follow their spectral characteristics in detail through model fitting. Colour-colour (CC) diagrams are therefore often used as alternative, model independent, tools to study the spectral variability of these sources. The INTEGRAL mission, with its(More)
A series of 3,4-diaryl-1,2,5-oxadiazoles and 3,4-diaryl-1,2,5-oxadiazole N-oxides were prepared and evaluated for COX-2 and COX-1 binding affinity in vitro and for antiinflammatory activity by the rat paw edema method. p-Methoxy (p-OMe) substituted compounds 9, 21, 34, 41, 42 showed COX-2 enzyme inhibition higher than that showed by compounds with other(More)
The latest all-sky survey in hard X-ray band was performed by the HEAO-1 satellite (13 − 80keV) with an angular resolution of 24 × 48arcmin. 13 A diffuse hard X-Ray background (HXB) was detected between 3 and 50keV. 16 The main scientific goal of In.XS is to resolve a large fraction of this HXB into individual sources. As no distortion by Compton(More)
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