Arvind N. Parmar

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The evolutionarily conserved peripheral benzodiazepine receptor (PBR), or 18-kDa translocator protein (TSPO), is thought to be essential for cholesterol transport and steroidogenesis, and thus life. TSPO has been proposed as a biomarker of neuroinflammation and a new drug target in neurological diseases ranging from Alzheimer's disease to anxiety. Here we(More)
X-ray observations have revealed that many microquasars and low-mass X-ray binaries (LMXBs) exhibit narrow absorption features identified with resonant absorption from Fexxv and Fexxvi and other abundant ions. In many well studied systems there is evidence for blue-shifts, indicating outflowing plasmas. We succesfully model the changes in both the X-ray(More)
Isavuconazole is a triazole with broad-spectrum activity against medically important fungal pathogens. We investigated the pharmacokinetics and pharmacodynamics of isavuconazole in a murine model of disseminated candidiasis. We determined the pharmacokinetics in both plasma and kidney. The relationship between tissue concentrations and the resultant(More)
High-sensitivity wide-band X-ray spectroscopy is the key feature of the Suzaku X-ray observatory, launched on 2005 July 10. This paper summarizes the spacecraft, in-orbit performance, operations, and data processing that are related to observations. The scientific instruments, the high-throughput X-ray telescopes, X-ray CCD cameras, non-imaging hard X-ray(More)
On 9-11 May 1998, BeppoSAX observed the low–luminous Seyfert 1 Galaxy NGC4051 in a ultra–dim X–ray state. The 2-10 keV flux (1.26× 10−12 erg cm−2 s−1) was about 20 times fainter than its historical average value, and remained steady along the whole observation (∼2.3 days). The observed flat spectrum (Γ ' 0.8) and intense iron line (EW'600 eV) are best(More)
We report on results of a target of opportunity observation of the X-ray transient XTE J1118+480 performed on 2000 April 14–15 with the Narrow Field Instruments (0.1–200 keV) of the BeppoSAX satellite. The measured spectrum is a power law with a photon index of ∼ 1.7 modified by an ultrasoft X-ray excess and a high-energy cutoff above ∼ 100 keV. The soft(More)
The present study investigates the effect of pioglitazone treatment on blood pressure, vascular reactivity and antioxidant enzymes in L-NAME induced hypertension in normal and STZ-diabetic rats. Diabetes was induced in male Sprague Dawley rats (200+/-15 g) by single intravenous injection of 55 mg/kg of streptozotocin (STZ). Rats were randomized into(More)
UNLABELLED The Inveon small-animal SPECT system comes with several types of multipinhole collimator plates. We evaluate here the performance measurements of the Inveon SPECT system using 6 different collimators: 3 dedicated for mouse imaging and 3 for rat imaging. METHODS The measured performance parameters include the sensitivity, the spatial resolution(More)
The 6.4 s X-ray pulsar 1E 1048.1–5937 was observed by BeppoSAX in 1997 May. This source belongs to the class of “anomalous” pulsars which have pulse periods in range 5–11 s, show no evidence of optical or radio counterparts, and exhibit long-term increases in pulse period. The phase-averaged 0.5–10 keV spectrum can be described by an absorbed powerlaw and(More)
It was envisaged to combine high antipyretic activity of paracetamol into commonly used NSAIDs. To achieve this goal new chemical entities were synthesized by chemically combining paracetamol and NSAIDs, and biologically evaluated for their antipyretic, analgesic, anti-inflammatory and ulcerogenic potential. The acid chloride of parent NSAIDs was reacted(More)