Arvind Gopinath

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Recent developments in computational cell and biomolecular mechanics have provided valuable insights into the mechanical properties of cells, subcellular components and biomolecules, while simultaneously complementing new experimental techniques used for deciphering the structure-function paradigm in living cells. These computational approaches have direct(More)
We consider the sticking of a fluid-immersed colloidal particle with a substrate coated by polymeric tethers, a model for soft, wet adhesion in many natural and artificial systems. Our theory accounts for the kinetics of binding, the elasticity of the tethers, and the hydrodynamics of fluid drainage between the colloid and the substrate, characterized by(More)
We experimentally investigate the effect of particle size on the motion of passive polystyrene spheres in suspensions of Escherichia coli. Using particles covering a range of sizes from 0.6 to 39 microns, we probe particle dynamics at both short and long time scales. In all cases, the particles exhibit super-diffusive ballistic behavior at short times(More)
Run-and-tumble motility is widely used by swimming microorganisms including numerous prokaryotic and eukaryotic organisms. Here, we experimentally investigate the run-and-tumble dynamics of the bacterium E. coli in polymeric solutions. We find that even small amounts of polymer in solution can drastically change E. coli dynamics: cells tumble less and their(More)
We study a continuum model of overdamped self-propelled particles with aligning interactions in two dimensions. Combining analytical theory and computations, we map out the phase diagram for the parameter space covered by the model. We find that the system self-organizes into two robust structures in different regions of parameter space: solitary waves(More)
We show that active, self-propelled particles that are connected together to form a single chain that is anchored at one end can produce the graceful beating motions of flagella. Changing the boundary condition from a clamp to a pivot at the anchor leads to steadily rotating tight coils. Strong noise in the system disrupts the regularity of the(More)
Deciphering the relationship between cellular processes and the structure of living cells is a key step toward understanding and predicting cell functions with direct implications for understanding human health and disease. The active nature of these cellular processes, which span several decades of spatial and temporal scales, pose significant challenges(More)
The motility of microorganisms is influenced greatly by their hydrodynamic interactions with the fluidic environment they inhabit. We show by direct experimental observation of the bi-flagellated alga Chlamydomonas reinhardtii that fluid elasticity and viscosity strongly influence the beating pattern - the gait - and thereby control the propulsion speed.(More)