Arvind Gopinath

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Recent developments in computational cell and biomolecular mechanics have provided valuable insights into the mechanical properties of cells, subcellular components and biomolecules, while simultaneously complementing new experimental techniques used for deciphering the structure-function paradigm in living cells. These computational approaches have direct(More)
We consider the sticking of a fluid-immersed colloidal particle with a substrate coated by polymeric tethers, a model for soft, wet adhesion in many natural and artificial systems. Our theory accounts for the kinetics of binding, the elasticity of the tethers, and the hydrodynamics of fluid drainage between the colloid and the substrate, characterized by(More)
We study a continuum model of overdamped self-propelled particles with aligning interactions in two dimensions. Combining analytical theory and computations, we map out the phase diagram for the parameter space covered by the model. We find that the system self-organizes into two robust structures in different regions of parameter space: solitary waves(More)
We show that active, self-propelled particles that are connected together to form a single chain that is anchored at one end can produce the graceful beating motions of flagella. Changing the boundary condition from a clamp to a pivot at the anchor leads to steadily rotating tight coils. Strong noise in the system disrupts the regularity of the(More)
Deciphering the relationship between cellular processes and the structure of living cells is a key step toward understanding and predicting cell functions with direct implications for understanding human health and disease. The active nature of these cellular processes, which span several decades of spatial and temporal scales, pose significant challenges(More)
Isotropic-nematic and nematic-nematic transitions from a homogeneous suspension of high aspect ratio magnetic rods are studied for both Maier-Saupe and Onsager excluded volume potentials. Asymptotic analysis in the vicinity of critical points yields insight into the stability and type of polarized nematic states emanating from nonpolarized equilibrium(More)
Long, elastic filaments cross-linked and deformed by active molecular motors occur in various natural settings. The overall macroscopic mechanical response of such a composite network depends on the coupling between the active and the passive properties of the underlying constituents and nonlocal interactions between different parts of the composite. In a(More)
Crosslinked semi-flexible and flexible filaments that are actively deformed by molecular motors occur in various natural settings, such as the ordered eukaryotic flagellum, and the disordered cytoskeleton. The deformation of these composite systems is driven by active motor forces and resisted by passive filament elasticity, and structural constraints due(More)
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