Arvind Aiyar

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Lindane (gamma-hexachlorocyclohexane) is an important organochlorine pesticide used extensively for agricultural and public health purposes in India and in other developing countries. Because of its relative chemical stability and lipid solubility, it is known to enter food chains. This study was carried out in order to identify the metabolic capacity of(More)
Plasmids containing oriP, the plasmid origin of Epstein-Barr virus (EBV), are replicated stably in human cells that express a single viral trans-acting factor, EBNA-1. Unlike plasmids of other viruses, but akin to human chromosomes, oriP plasmids are synthesized once per cell cycle, and are partitioned faithfully to daughter cells during mitosis. Although(More)
Epstein-Barr viral nuclear antigen-1 (EBNA-1) is required for the stable replication of plasmids that contain oriP, the origin of DNA synthesis used during the latent phase of the Epstein-Barr virus life cycle. EBNA-1 acts post-synthetically through unknown mechanisms to facilitate the continued synthesis of oriP plasmids in ensuing S phases. In contrast to(More)
3. K. Ichihara. E. Kusunose and M. Kusunose, Biochim. 7. J. L. Maggs. A. H. Olavesen and C. T. James. J. biophps. Acta 176. 704 (1969). labelled Compds Radiopharmaceuticals 17. 793 (1980). 4. K. K. Stanley and P. K. Tubbs. Biochem. J. 150, 77 8. C. G. Curtis. G. M. Powell and S. L. Stone, J. Physiol., (1975). Land. 213, 14P (1970). 5. W. H. B. Denner. A. H.(More)
The effects of chronic diet restriction in mice on some biochemical parameters related to aging have been investigated. Restriction of food intake to about one-half of the ad libitum consumption resulted in a significantly decreased growth rate immediately after weaning. In the experimental mice killed after different periods on a restricted diet up to 12(More)
An investigation was undertaken to study the effect of dietary protein level on some age-related biochemical processes in mice. Weanling mice were fed a laboratory diet containing protein at 6, 12 or 24% and adequate in all other nutrients, for up to 52 weeks. Although the rate of gain in body weight of the animals between 3 and 6 weeks was related to the(More)
Irradiated sugar solutions are mutagenic towards Salmonella typhimurium, the effect being dose-dependent up to 2.0 Mrad. At all doses, ribose solution exhibited greater mutagenicity than did sucrose solution. The mutagenic effect was observed only in dividing cells and appears to be directly related to the growth rate. A larger proportion of revertants was(More)