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- Karim Nayernia, Jessica Nolte, +12 authors Wolfgang Engel
- Developmental cell
- 2006
Male gametes originate from a small population of spermatogonial stem cells (SSCs). These cells are believed to divide infinitely and to support spermatogenesis throughout life in the male. Here, we… (More)
- Pradeep Sathyanarayana, Arvind A. Dev, +8 authors Don M. Wojchowski
- Blood
- 2008
EPO functions primarily as an erythroblast survival factor, and its antiapoptotic actions have been proposed to involve predominantly PI3-kinase and BCL-X pathways. Presently, the nature of… (More)
- Nadja Drusenheimer, Gerald G. Wulf, +7 authors Karim Nayernia
- Society of Reproduction and Fertility supplement
- 2007
Germ cells must develop along distinct male or female paths to produce the spermatozoa or oocyte required for sexual reproduction. Male germline stem cells maintain spermatogenesis in the postnatal… (More)
- Don M. Wojchowski, Pradeep Sathyanarayana, Arvind A. Dev
- Current opinion in hematology
- 2010
PURPOSE OF REVIEW
In 1985-1989, erythropoietin (EPO), its receptor (EPOR), and janus kinase 2 were cloned; established to be essential for definitive erythropoiesis; and initially intensely studied.… (More)
Investigations of bone marrow (BM) erythroblast development are important for clinical concerns but are hindered by progenitor cell and tissue availability. We therefore sought to more specifically… (More)
- Arvind A. Dev, Susan M. Byrne, Rakesh Verma, Philip G. Ashton-Rickardt, Don M. Wojchowski
- The Journal of experimental medicine
- 2013
Erythropoietin (EPO) and its cell surface receptor (EPOR) are essential for red blood cell production and exert important cytoprotective effects on select vascular, immune, and cancer cells. To… (More)
- Olga Bogacheva, Oleg Bogachev, +12 authors Don M. Wojchowski
- The Journal of biological chemistry
- 2008
During anemia erythropoiesis is bolstered by several factors including KIT ligand, oncostatin-M, glucocorticoids, and erythropoietin. Less is understood concerning factors that limit this process.… (More)
- Seema Singh, Arvind A. Dev, +5 authors Don M. Wojchowski
- PloS one
- 2012
Certain concepts concerning EPO/EPOR action modes have been challenged by in vivo studies: Bcl-x levels are elevated in maturing erythroblasts, but not in their progenitors; truncated EPOR alleles… (More)
Sprouty proteins are established modifiers of receptor tyrosine kinase (RTK) signaling and play important roles in vasculogenesis, bone morphogenesis, and renal uteric branching. Little is… (More)
- Arvind A. Dev, Ruth Asch, +4 authors Don M. Wojchowski
- Experimental hematology
- 2017
In response to anemia, the heightened production of erythropoietin (EPO) can sharply promote erythroid progenitor cell (EPC) formation. Specific mediators of such EPO- accelerated erythropoiesis,… (More)