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Non-Syndromic Hearing Impairment in India: High Allelic Heterogeneity among Mutations in TMPRSS3, TMC1, USHIC, CDH23 and TMIE
New mutations detected in this study extend the allelic heterogeneity of the genes and provide several additional variants for structure-function correlation studies and have implications for early DNA-based detection of deafness and genetic counseling of affected families in the Indian subcontinent. Expand
Life Events in Acute and Transient Psychosis-A Comparison with Mania
Background: The temporal association between stressful life events and the onset of psychiatric disorders necessitates clinical investigation. In acute and transient psychoses (ATPD) such stressorsExpand
Internal predictors of burnout in psychiatric nurses: An Indian study
Emotional maturity, adjustability, sense of general physical well-being as well as prior military training significantly predicted lower burnout, and emotional maturity was the most important predictor. Expand
Impact of Substance Use Disorder on Presentation and Short-Term Course of Schizophrenia
Schizophrenia patients with SUD should be carefully assessed for presence of depression, as SUD appeared to mask abstraction difficulties at presentation. Expand
Clozapine-Induced Oculogyric Crises
Clozapine appears to be the cause of the oculogyric crises of a 37-year-old Indian man with chronic paranoid schizophrenia, and this viewpoint is consistent with the Naranjoprobabilityscale, which indicates a probablerelationship between theoculogicalric crises andclozapines pharmacotherapy. Expand
A novel locus DFNA59 for autosomal dominant nonsyndromic hearing loss maps at chromosome 11p14.2–q12.3
A three-generation family with 14 of its members manifesting ADNSHL is analyzed, using a genome-wide linkage mapping approach, and a novel locus DFNA59 is found in the chromosome location 11p14.2–q12.3. Expand
Predictors of Suicide Attempt Among those with Depression in an Indian Sample: A Brief Report
Background: Cultural variation may influence the impact of different risk factors of suicide. Indian data about risk factors for suicidal attempt among those with major depressive disorder isExpand
Olanzapine-induced oculogyric crisis in a patient with schizophrenia.
The patient gave a history of taking NSAIDS for vague abdominal pain, for almost a year; and the probability score by Naranjo algorithm for NSAIDS use and hemoperitoneum calculates to 0 [doubtful adverse drug reaction]. Expand
Relative quantification of human β-defensins by a proteomics approach based on selected reaction monitoring.
The results demonstrate that the developed SRM method offers an alternative approach for the cost-effective and rapid analysis of human β-defensins in samples with biological relevance. Expand
Neuroplasticity--a paradigm shift in neurosciences.
Neuroplasticity research has now established beyond doubt that the brain is actually a dynamic system of neural network that has the capability of significant growth under favourable circumstances, which opens up new possibilities in treatment of disorders where neural loss or synaptic decay is major factor in molecular aetiopathogeneis. Expand