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DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity
DLK is part of a specialized JNK signaling complex in axons that promotes apoptosis via c-Jun but axon degeneration via distinct JNK substrates.
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JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis
Neuronal injury induces JNK phosphorylation of DLK, which reduces DLK ubiquitination and creates a positive feedback loop to enhance JNK signaling and increase apoptosis.
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Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models.
Dual leucine zipper kinase (DLK, MAP3K12) was recently identified as an essential regulator of neuronal degeneration in multiple contexts. Here we describe the generation of potent and selective DLKExpand
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Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12).
Recent data suggest that inhibition of dual leucine zipper kinase (DLK, MAP3K12) has therapeutic potential for treatment of a number of indications ranging from acute neuronal injury to chronicExpand
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Sca ff old-Hopping and Structure-Based Discovery of Potent , Selective , And Brain Penetrant N ‐ ( 1 H ‐ Pyrazol-3-yl ) pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase ( DLK , MAP 3 K 12 )
Recent data suggest that inhibition of dual leucine zipper kinase (DLK, MAP3K12) has therapeutic potential for treatment of a number of indications ranging from acute neuronal injury to chronicExpand
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