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Nuclear Innate Immune DNA Sensor IFI16 Is Degraded during Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus (KSHV): Role of IFI16 in Maintenance of KSHV Latency
TLDR
It is demonstrated that knockdown of IFI16 in the latently KSHV-infected B-lymphoma BCBL-1 and BC-3 cell lines results in lytic reactivation and increases in levels of K SHV lytic transcripts, proteins, and viral genome replication. Expand
Herpesvirus Genome Recognition Induced Acetylation of Nuclear IFI16 Is Essential for Its Cytoplasmic Translocation, Inflammasome and IFN-β Responses
TLDR
These studies identify the increased nuclear acetylation of IFI16 as a dynamic essential post-genome recognition event in the nucleus that is common to the IFI 16-mediated innate responses of inflammasome induction and IFN-β production during herpesvirus (KSHV, EBV, HSV-1) infections. Expand
Spatiotemporal Analysis of Bacterial Diversity in Sediments of Sundarbans Using Parallel 16S rRNA Gene Tag Sequencing
TLDR
The results of this study add valuable information about the composition of microbial communities in Sundarbans mangrove and shed light on possible transformations promoted by bacterial communities in the sediments. Expand
BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses
TLDR
It is demonstrated that BRCA1, a DNA damage repair sensor and transcription regulator, is in complex with IFI16 in the host cell nucleus, and their association increases in the presence of nuclear viral genomes during de novo KshV, EBV and HSV-1 infection, and in latent KSHV or EBV infection, but not by DNA damage responses induced by bleomycin and vaccinia virus cytoplasmic dsDNA. Expand
ESCRT-I Protein Tsg101 Plays a Role in the Post-macropinocytic Trafficking and Infection of Endothelial Cells by Kaposi’s Sarcoma-Associated Herpesvirus
TLDR
The studies reveal that Tsg101 plays a role in the trafficking of macropinocytosed KSHV in the endothelial cells which is essential for the successful viral genome delivery into the nucleus, viral gene expression and infection. Expand
Wnt5a–Rac1–NF-κB Homeostatic Circuitry Sustains Innate Immune Functions in Macrophages
TLDR
It is demonstrated that innate immune functions of macrophages ensue at least partly through a homeostatic Wnt5a–Fz5–NF-κB (p65) circuit, which is Rac1 dependent. Expand
Histone H2B-IFI16 Recognition of Nuclear Herpesviral Genome Induces Cytoplasmic Interferon-β Responses
TLDR
H2B is identified as an innate nuclear sensor mediating a novel extra chromosomal function, and two IFI16 complexes mediate KSHV and HSV-1 infection. Expand
IFI16, a nuclear innate immune DNA sensor, mediates epigenetic silencing of herpesvirus genomes by its association with H3K9 methyltransferases SUV39H1 and GLP
TLDR
It is shown that IFI16 is in complex with the H3K9 methyltransferase SUV39H1 and GLP and recruits them to the KSHV genome during de novo infection and latency and establishes an important paradigm of an innate immune sensor’s involvement in epigenetic silencing of foreign DNA. Expand
Changing bacterial profile of Sundarbans, the world heritage mangrove: Impact of anthropogenic interventions
TLDR
Sediment bacterial diversity of the Sundarbans is explored using a culture-independent molecular approach and indicates that sites with similar exposure to differential anthropogenic intervention reflect similar patterns of microbial diversity besides spatial commonalities. Expand
Activated Nrf2 Interacts with Kaposi's Sarcoma-Associated Herpesvirus Latency Protein LANA-1 and Host Protein KAP1 To Mediate Global Lytic Gene Repression
TLDR
It is demonstrated that Nrf2 plays an important role in KSHV gene expression, lytic reactivation, and cell survival by interacting with the host transcriptional repressor KAP1 and the viral latency-associated protein LANA-1 to mediate global lytic gene repression and thus cell survival. Expand
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