Arunakaran Jagadeesan

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BACKGROUND There is increasing evidence suggesting the role of free radicals in bone resorption and bone loss. Ovariectomized rats have been used as the animal model for the study of osteoporosis. Oxidative stress due to reactive oxygen species (ROS) can cause oxidative damage to cells. Cells have a number of defense mechanisms to protect themselves from(More)
The present study aims to investigate the protective effect of quercetin against Aroclor-1254-induced hepatotoxicity in rats. Male Wistar rats were grouped into Group I control received vehicle (corn oil; 1 mL/kg bwt); Group II quercetin alone (50 mg/kg bwt/day orally); Group III Aroclor-1254 (2 mg/kg bwt/day intraperitoneally); Group IV Aroclor-1254 +(More)
Phthalates are the largest group of environmental pollutants and are considered toxicant to the endocrine system. The present study was aimed to test the effect of in utero exposure of di(2-ethylhexyl)phthalate (DEHP) on Leydig cell steroidogenesis in F1 male offspring's. Pregnant dams were oral gavaged with different doses (1, 10, and 100 mg/kg/day) of(More)
7, 12-dimethylbenz (a)anthracene(DMBA) acts as a potent site and organ specific carcinogen by generating various reactive metabolic intermediates leading to oxidative stress. Female Sprague Dawley rats were divided into four groups and each group consisting of six animals. Group I and group IV were vector and drug control. The group II and group III animals(More)
Prostate cancer is the most common malignancy and the second leading cause of cancer death in the male population in developing countries. Ukrain is a reaction product of different alkaloids from Chelidoniummajus L. (celandine) conjugated with thiophosphoric acid, which has cytotoxic effects on various malignant cells. In the present study, cell viability(More)
The present investigation was carried out to estimate the effect of bioactive compound limonin on various biological enzymes like Glycogen; Membrane bound ATPases, Carbohydrate metabolizing enzymes and Mitochondrial TCA cycle enzymes against N-nitrosodiethylamine (DEN) induced primary liver cancer in male Wistar albino rats. Liver cancer was induced by(More)
Di(2-ethylhexyl) phthalate (DEHP) is a ubiquitous environmental contaminant and a well-known endocrine disruptor (ED) that interferes with the reproductive function in both humans and animals. This study aimed to find out the impact of lactational exposure of DEHP in testes of first filial generation (F1) progeny male rat postnatal day (PND)-60. Lactating(More)
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