Learn More
Biological properties of renal-specific oxidoreductase (RSOR), characteristics of its promoter, and underlying mechanisms regulating its expression in diabetes were analyzed. RSOR expression, normally confined to the renal cortex, was markedly increased and extended into the outer medullary tubules in db/db mice, a model of type 2 diabetes. Exposure of(More)
BACKGROUND AND AIMS HCV GT-3 has a more pronounced effect on hepatic steatosis and host lipids than other HCV genotypes and is proving less responsive to all oral interferon-free treatment with direct acting antiviral agents. As both HCV GT3 infection and NASH can result in steatosis and cirrhosis, we asked whether hepatic transcriptional profiles(More)
BACKGROUND Renal-specific oxidoreductase (RSOR) has been recently identified in mice kidneys of diabetic animals, and it is developmentally regulated. Its expression during fetal, neonatal, and postnatal periods was assessed under high glucose ambience. METHODS Whole-mount immunofluorescence and confocal microscopy were performed to assess the effect of(More)
Scaling of the on-chip feature size and power supply voltage have significantly reduced the noise margins of an integrated circuit and have aggravated the effects of process and enviromental variations. These effects can introduce delay variations on the signals within a circuit, possibly causing a violation of the timing constraints in a clocked register(More)
  • 1