Arun Rasheed

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The cyclodextrins have a wide range of applications in different areas of drug delivery and pharmaceutical industry due to their complexation ability and other versatile characteristics. The most common pharmaceutical application of cyclodextrin is to enhance the solubility, stability, safety and bioavailability of drug molecules. The purpose of this review(More)
The gastrointestinal toxicity associated with aceclofenac can be reduced by condensing its carboxylic acid group with methyl esters of amino acids like histidine and alanine to give amide linkage by the Schotten-Baumann method. Physicochemical characterization of the conjugates was carried out by various analytical and spectral methods. The synthesized(More)
The moisture content present in human skin makes it look young and the use of moisturizer results in fastening the moisture with a surface film of oil. Acne vulgaris is one of the most commonly seen diseases among the youth. The present study is focused on the use of herbs as moisturizer for acne treatment. The anti-acne moisturizer was formulated from(More)
The filarial parasites were considered causing remarkable problems for the human beings and animals. Many modern synthetic medicines found to be very effective in curing diseases cause a lot of side effects. The natural drugs were proven to have less side effects inspite their reletively low activity. A large number of medicinal plants were claimed to(More)
Ayurvedic formulations were considered the best and safer alternatives for synthetic drugs. But the demand to such products is diminishing due to lack of standardization. Ashwagandharishtam, a fermented kind of ayurvedic formulation, is used to treat epilepsy, nervous disorders, skin diseases, immune disorders and rheumatism. In the present study, the(More)
Natural substances extracted from plants have recently been considered as potential sunscreen resources owing to high ultraviolet ray absorption and antioxidant activity. The decrease in the intensity of UV radiation reaching the skin through sunscreens may reduce the risk of sun-induced skin cancer. The present study attempts to develop sunscreen lotions,(More)
CONTEXT Bosentan is a poorly soluble drug and pose challenges in designing of drug delivery systems. OBJECTIVE The objective of this study is to enhance the solubility, dissolution and shelf-life of bosentan by formulating it as S-SMEDDS capsules. MATERIALS AND METHODS Solubility of bosentan was tested in various liquid vehicles such as oils (rice bran(More)
Argemone mexicana (L.) has a role in the treatment of epileptic disorders in Indian traditional system of medicine. We studied its effect on induced status epilepticus (SE) and oxidative stress in rats. SE was induced in male albino rats by administration of pilocarpine (30 mg/kg, ip) 24 h after injection of lithium chloride (3 mEq/kg, ip). Different doses(More)
Two-dimensional QSAR models were produced by stepwise multiple-linear regression and 3D QSAR models were developed by k-nearest neighbor-molecular field analysis on a database consists of 18 diaryl pyrimidine analogs. The developed QSAR model was evaluated for statistical significance and predictive power. The key conclusion of this study is that the(More)
Synthesis, physicochemical characterization and pharmacological evaluation of mutual prodrugs of aceclofenac with quercetin, vanillin and l-tryptophan have been attempted to develop novel gastrosparing NSAIDs, devoid of ulcerogenic side effects. The structures of synthesized prodrugs were confirmed by IR, 1H NMR, 13C NMR and mass spectroscopy. The(More)