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In recent years, the US Food and Drug Administration has encouraged pharmaceutical companies to develop more innovative and efficient manufacturing methods with improved online monitoring and control. Mini-manufacturing of medicine is one such method enabling the creation of individualized product forms for each patient. This work presents dropwise additive(More)
Three different approaches have been evaluated for monitoring ribbon density through real-time near-infrared spectroscopy measurements. The roll compactor was operated to produce microcrystalline cellulose (MCC) ribbons of varying densities. The first approach used the slope of the spectra which showed a variation through the ribbon that could be attributed(More)
The US Food and Drug Administration introduced the quality by design approach and process analytical technology guidance to encourage innovation and efficiency in pharmaceutical development, manufacturing, and quality assurance. As part of this renewed emphasis on the improvement of manufacturing, the pharmaceutical industry has begun to develop more(More)
This paper presents a real-time process management (RTPM) strategy for Dropwise Additive Manufacturing of Pharmaceutical Products (DAMPP), a mini-manufacturing method for pharmaceutical dosage forms. The semicontinuous, small-scale nature of DAMPP allows for more automation and control than traditional large-scale batch pharmaceutical manufacturing(More)
The features of a drop-on-demand-based system developed for the manufacture of melt-based pharmaceuticals have been previously reported. In this paper, a supervisory control system, which is designed to ensure reproducible production of high quality of melt-based solid oral dosages, is presented. This control system enables the production of individual(More)
—In this work we consider the performance of turbo coded OFDM systems in the presence of co-channel interference (CCI) in reuse-1 OFDM systems such as 802.16d/e and LTE. Because of frequency selectivity and diversity mapping, CCI does not affect all the subcarriers of the desired user. Hence CCI behaves like Narrow Band Interference(NBI) with the number of(More)
The improvements in healthcare systems and the advent of the precision medicine initiative have created the need to develop more innovative manufacturing methods for the delivery and production of individualized dosing and personalized treatments. In accordance with the changes observed in healthcare systems towards more innovative therapies, this paper(More)