Arumugam Premkumar

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3,4-Methylenedioxymethamphetamine (MDMA or Ecstasy) is a widely abused drug. In brains of mice exposed to MDMA, we recently detected altered expression of several cDNAs and genes by using the differential display polymerase chain reaction (PCR) method. Expression of one such cDNA, which exhibited 98% sequence homology with the synaptic vesicle protein(More)
The Vpr protein of HIV-1 functions as a vital accessory gene by regulating various cellular functions, including cell differentiation, apoptosis, nuclear factor of kappaB (NF-kappaB) suppression and cell-cycle arrest of the host cell. Several reports have indicated that Vpr complexes with the glucocorticoid receptor (GR), but it remains unclear whether the(More)
Objectives A hallmark of several neurodegenerative diseases is the progressive death of neuronal cells in the central or peripheral nervous system. Neurons, like other cells in our body, are vulnerable to toxins and oxidizing agents, some of which are self-made. It is well established, e.g., that a number of endogenous brain chemicals, including the(More)
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