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The aim of this study was to evaluate the WCST, a task linked to the frontal (prefrontal) cortex, in normal twins to detect an inherited component of frontal lobe function. The WCST scores of 15 monozygotic (MZ) twin pairs, 9 dizygotic (DZ) twin pairs, and 15 unrelated control pairs were used to compute genetic estimates. No significant differences were(More)
OBJECTIVE To verify whether features of CNS involvement can be detected in SLE patients without overt neuropsychiatric manifestations. METHODS 114 SLE patients who had never received a diagnosis of neuropsychiatric lupus (never-NPSLE) were studied and compared to 65 SLE patients with known neuropsychiatric involvement (NPSLE). The study relied on(More)
Many clinical and research findings converge to indicate that frontal lobe, basal ganglia, and related neuronal connections are primarily involved in human immunodeficiency virus (HIV) infection; frontal lobe, mainly the prefrontal cortex, has a specialized role in working memory processes. This study focused on neuropsychological evaluation of the spatial(More)
BACKGROUND The presence of psychiatric disorders (according to DSM-III-R), the discriminating power of a psychiatric structured interview, and sleep monitoring were investigated in psychophysiological insomnia. METHOD Forty young (20-40 years old) patients, selected for putative psychophysiological insomnia, underwent a psychiatric structured interview(More)
Several researchers have underscored the importance of precise characterization of eye-tracking dysfunction (ETD) in patients with schizophrenia. This biological trait appears to be useful in estimating the probability of genetic recombination in an individual, so it may be helpful in linkage studies. This article describes a nonlinear computational model(More)
Several authors have investigated the presence of thought disorder in psychiatric patients using different reliable methods. Under the hypothesis of a genetic predisposition to thought disorder, the degree and quality of thought disorder have also been studied in populations at a high risk for psychosis, in particular for schizophrenia. As a result, an(More)
This study used eye tracking movement tests to examine the relationships between frontal field functions and clinical features. Smooth pursuit and voluntary saccadic eye movements were recorded and analyzed in 34 delusional disorder (DD) patients and in 40 normal subjects. The DD group differed significantly from the group of normal subjects in some eye(More)
The authors obtained a frontal functions profile for 81 schizophrenic patients using six neuropsychological tests that evaluate the dorsolateral prefrontal cortex functions, i.e., working memory, executive functions, and strategic performance. They then analyzed the test performances with a cluster analysis, which produced a four-cluster solution. The(More)
OBJECTIVE Cognitive Behavioural Therapy for the treatment of Social Phobia has proved effective through several controlled trials and meta-analyses. In spite of this the CBT has not spread in clinical field yet. Therefore our aim was to verify the effectiveness of the CBT in a public mental health service and to compare our results with those described by(More)
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