Arto Määttä

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The cornified envelope is assembled from transglutaminase cross-linked proteins and lipids in the outermost epidermal layers and is essential for skin barrier function. Involucrin, envoplakin, and periplakin form the protein scaffold on which the envelope assembles. To examine their combined function, we generated mice deficient in all three genes. The(More)
Envoplakin and periplakin are two plakins that are precursors of the epidermal cornified envelope. We studied their distribution and interactions by trans-fection of primary human keratinocytes and other cells. Full-length periplakin localized to desmosomes, the in-terdesmosomal plasma membrane and intermediate filaments. Full length envoplakin also(More)
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