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Inhibition of the LSD 1 ( KDM 1 A ) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
Acute promyelocytic leukemia (APL), a cytogenetically distinct subtype of acute myeloid leukemia (AML), characterized by the t(15;17)-associated PML-RARA fusion, has been successfully treated with
Evaluation of acute and subchronic toxicity of Annona muricata (Linn.) aqueous extract in animals
Annona muricata is an important underutilized plant with established hepatoprotective effect against carbon tetrachloride and acetaminophen and can treat hepatic jaundice. The present study was
The kinases MSK 1 and MSK 2 act as negative regulators of Toll-like receptor signaling
MSK1 and MSK2 kinases are activated downstream of the p38 and ERK1/2 MAPK kinases. Here we found that MSK1 and MSK2 are required to limit the production of pro-inflammatory cytokines in response to
Considerable evidence has accumulated from studies in vivo and with tissue slices indicating that erotic acid (4-carboxyuracil), or a closely related compound, is a precursor of the pyrimidines in
By acute retention is meant a sudden and complete inability to pass urine. A chronic retention means that the patient is unable to empty the bladder, though micturition is still possible, and may
Primase, the dnaG Protein of Escherichia coZi
The dnaG protein is highly specific for G4 DNA and synthesizes a unique 29-residue RNA primer to be described in the paper, which has an apparent K, for ribonucleoside triphosphates near 10.
Title : Restoring Mucosal Barrier Function and Modifying Macrophage Phenotype with an Extracellular Matrix Hydrogel : Potential Therapy for Ulcerative Colitis
Background & Aims: Despite advances in therapeutic options, more than half of all patients with ulcerative colitis (UC) do not achieve long-term remission, many require colectomy, and the disease
Nerve Terminal Damage in Cerebral Ischemia : Greater Susceptibility of Catecholamine Nerve Terminals Relative to Serotonin Nerve Terminals
Two patients developed paraplegia associated with the use of the intraaortic balloon pump. In one patient, transient spinal ischemic episodes ceased after removal of the intraaortic balloon and the
Depletion of the erbB2 Gene Product p 185 by Benzoquinoid Ansamycins
this inhibition (15). Although the mechanism is unclear, herbimycin (0.88 !.LM)reduces protein phosphotyrosine levels in treated cells transformed by src, ros, or erbB oncogenes (8, 10), and