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Reducing food intake in lower animals such as the rat decreases body weight, retards many aging processes, delays the onset of most diseases of old age, and prolongs life. A number of clinical trials of food restriction in healthy adult human subjects running over 2-15 years show significant reductions in body weight, blood cholesterol, blood glucose, and(More)
The course of aging in most endocrine glands is moderately well documented in man, but is somewhat less understood in the rat. With increasing age in man there is a significant decline in the secretion of hormones by the thyroid, adrenal cortex, testis and ovary; pituitary growth hormone falls but gonadotrophins rise. In man decline in the secretion of(More)
Long-term reduction in energy intake in the diet (calorie restriction [CR]) extends the life of the laboratory rat by about 25%. However, in humans there are no life-long studies of CR, but only short-term trials which indicate that 20% CR acting over periods of 2-6 years is associated with reduced body weight, blood pressure, blood cholesterol, and blood(More)
This communication reports on the effects of ageing, hypophysectomy and food restriction on the fibre sizes of the soleus muscle which is primarily concerned with posture. The results reported here are compared with those previously shown for the gastrocnemius muscle which is involved mainly with locomotion. Muscle fibre size (measured as equivalent circle(More)
Hypophysectomy in young male Wistar rats aged 70 days, followed by cortisone acetate replacement therapy throughout life, retarded the rate of aging of tail tendon collagen fibres, inhibited the development of certain diseases of old age (renal disease, cardiac enlargement, hind limb paralysis, and various endocrine and non-endocrine tumors) and(More)
This study investigated the effects of either growth hormone or thyroxine on muscle fiber atrophy caused by hypophysectomy in male Wistar rats. Muscle fiber size is reported as equivalent circle diameter (ECD) in transverse section of fresh-frozen gastrocnemius muscle. Three months post-hypophysectomy type 1 (slow twitch) and type 2 (fast twitch) muscle(More)