• Publications
  • Influence
Acute respiratory distress syndrome: the Berlin Definition.
TLDR
The updated and revised Berlin Definition for ARDS addresses a number of the limitations of the AECC definition and may serve as a model to create more accurate, evidence-based, critical illness syndrome definitions and to better inform clinical care, research, and health services planning. Expand
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury
TLDR
A molecular explanation why SARS-CoV infections cause severe and often lethal lung failure and suggest a rational therapy for SARS and possibly other respiratory disease viruses is provided. Expand
Driving pressure and survival in the acute respiratory distress syndrome.
TLDR
It is found that ΔP was the ventilation variable that best stratified risk and decreases in ΔP owing to changes in ventilator settings were strongly associated with increased survival. Expand
Angiotensin-converting enzyme 2 protects from severe acute lung failure
TLDR
It is reported that ACE2 and the angiotensin II type 2 receptor (AT2) protect mice from severe acute lung injury induced by acid aspiration or sepsis, pointing to a possible therapy for a syndrome affecting millions of people worldwide every year. Expand
Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries.
TLDR
Clinician recognition of ARDS was associated with higher PEEP, greater use of neuromuscular blockade, and prone positioning, which indicates the potential for improvement in the management of patients with ARDS. Expand
Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model.
TLDR
The concept that mechanical ventilation can have a significant influence on the inflammatory/anti-inflammatory milieu of the lung, and thus play a role in initiating or propagating a local, and possibly systemic inflammatory response, is supported. Expand
Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury
TLDR
It is reported that Toll-like receptor 4 (TLR4) mutant mice display natural resistance to acid-induced acute lung injury (ALI), and it is shown that TLR4-TRIF-TRAF6 signaling is a key disease pathway that controls the severity of ALI. Expand
Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis.
TLDR
Evaluating the association of higher vs lower PEEP with patient-important outcomes in adults with acute lung injury or ARDS who are receiving ventilation with low tidal volumes found that higher levels were associated with improved survival among the subgroup of patients with ARDS, but lower levels were not associated withImproved hospital survival. Expand
One-year outcomes in survivors of the acute respiratory distress syndrome.
TLDR
The absence of systemic corticosteroid treatment, the absence of illness acquired during the intensive care unit stay, and rapid resolution of lung injury and multiorgan dysfunction were associated with better functional status during the one-year follow-up. Expand
An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals.
TLDR
This list of features and measurements of ALI is intended as a guide for investigators, and ultimately investigators should choose the particular measurements that best suit the experimental questions being addressed as well as take into consideration any unique aspects of the experimental design. Expand
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