Arthur S. Ding

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Radix Salviae Miltiorrhizae (RSM), a well-known traditional Chinese medicinal herb, has been used to improve blood circulation and resolve blood stasis. We have previously found that RSM has neuroprotective effect on ischemia and/or ischemia-reperfusion rats. The purpose of this study was to obtain further information on the mechanism of the RSM-induced(More)
The effects of recombinant human interleukin-1 beta (rhIL-1 beta) and interleukin-2 (rhIL-2) on the cultured rat hippocampal neurons were investigated with intracellular recording and extracellular micropressure ejection techniques. Experimental results showed that all of the neurons tested with rhIL-1 beta (100 U/ml) exhibited a 4.20 +/- 1.86 mV membrane(More)
Hypoxic preconditioning with different simulated altitudes (3,000 m and 5,000 m) was performed on Wistar rats and the evoked population spikes were recorded from the hippocampal slices of these rats. The results showed that the appearance of hypoxic injury potential (HIP) and the disappearance of presynaptic volley (PV) were significantly delayed in(More)
AIM To investigate the effects of intermittent hypoxia on the hippocampal synaptic plasticity in rat. METHODS The evoked potentials were recorded extracellularly, then the LTP were induced by tetanic stimulation in rat hippocampal dentate gyrus. RESULTS Compared with control group, the amplitude of LTP was significantly reduced in hippocampus of rat(More)
AIM To study the protective effect of ginsenosides (Gin) against anoxic injury in brain cells. METHODS On d 12 after plating of the hippocampal cells from newborn rat, the cultures were exposed to anoxic atmosphere (95% N2 + 5% CO2) for 4-24 h. The cellular morphology, survival rate, and effluxes of lactate dehydrogenase (LDH) and K+ from cells were(More)
Rat hippocampal slices placed in two compartments of a dual chamber were immersed in the superfusing artificial cerebrospinal fluid (ACSF) with 95% O2 + 5% CO2. The population spike (PS) and presynaptic fiber volley (PV) were recorded in CA1 pyramidal cells by stimulating Schaffer collateral pathways. Following hypoxia produced by replacing O2 with N2, the(More)
Batroxobin, the thrombin-like enzyme, is used for therapeutic defibrination. We have found that batroxobin has good therapeutic effect in ischemic reperfusion rats and clinical practices in vivo. But we have not studied the neuroprotective effect of batroxobin on anoxic hippocampal neurons in vitro. The purpose of this study was to obtain further(More)
Effects of Na+/Ca2+ exchange blocker, Benzamil, on rat hippocampal slices and on cultured hippocampal neuronal [Ca2+]i (intracellular free Ca2+ concentration) during anoxia were investigated by means of microelectrode recording technique and laser scanning confocal microscope respectively. The results showed that the PV sustained time of hippocampal slices(More)
OBJECTIVE To investigate the pathological features of renal clear cell carcinoma (RCCC) in children and its relationship to the DNA content of cancer cells and DNA ploidy. METHODS The pathologic morphology of 4 cases of RCCC in children were observed. Using image analysis instruments the quantity of tumor cell DNA was measured. RESULTS The cytoplasm of(More)