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Cellular Delivery of Doxorubicin via pH-Controlled Hydrazone Linkage Using Multifunctional Nano Vehicle Based on Poly(β-L-Malic Acid)

• Rameshwar Patil, Jose Antonio Portilla-Arias, +6 authors Julia Y. Ljubimova
• International journal of molecular sciences
• 2012

Doxorubicin (DOX) is currently used in cancer chemotherapy to treat many tumors and shows improved delivery, reduced toxicity and higher treatment efficacy when being part of nanoscale delivery… (More)

Nanomedicine therapeutic approaches to overcome cancer drug resistance.

• Janet L. Markman, Arthur Rekechenetskiy, Eggehard Holler, Julia Y. Ljubimova
• Advanced drug delivery reviews
• 2013

Nanomedicine is an emerging form of therapy that focuses on alternative drug delivery and improvement of the treatment efficacy while reducing detrimental side effects to normal tissues. Cancer drug… (More)

Toxicity and efficacy evaluation of multiple targeted polymalic acid conjugates for triple-negative breast cancer treatment.

• Julia Y. Ljubimova, Jose Antonio Portilla-Arias, +10 authors Eggehard Holler
• Journal of drug targeting
• 2013

Engineered nanoparticles are widely used for delivery of drugs but frequently lack proof of safety for cancer patient's treatment. All-in-one covalent nanodrugs of the third generation have been… (More)

MRI virtual biopsy and treatment of brain metastatic tumors with targeted nanobioconjugates: nanoclinic in the brain.

• Rameshwar Patil, Alexander V Ljubimov, +14 authors Julia Y. Ljubimova
• ACS nano
• 2015

Differential diagnosis of brain magnetic resonance imaging (MRI) enhancement(s) remains a significant problem, which may be difficult to resolve without biopsy, which can be often dangerous or even… (More)

Curcumin Targeted, Polymalic Acid-Based MRI Contrast Agent for the Detection of Aβ Plaques in Alzheimer's Disease.

• Rameshwar Patil, Pallavi R. Gangalum, +8 authors Eggehard Holler
• Macromolecular bioscience
• 2015

Currently, there is no gadolinium-based contrast agent available for conventional magnetic resonance imaging (MRI) detection of amyloidal beta (Aβ) plaques in Alzheimer's disease (AD). Its timely… (More)

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

• Julia Y. Ljubimova, Hui Ding, +8 authors Eggehard Holler
• Journal of visualized experiments : JoVE
• 2014

Tumors with similar grade and morphology often respond differently to the same treatment because of variations in molecular profiling. To account for this diversity, personalized medicine is… (More)

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