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Genetic methods of antibody generation offer a highly tuneable tool for the production of target specific reagents suitable for a wide range of applications, including immunohistochemistry. The direct linkage between binder phenotype and genotype enables the rapid identification and manipulation of specific binders into formats suitable for highly specific(More)
A rather unique panel tracking more than 3300 individuals from households in rural Kagera, Tanzania during 1991/4-2010 shows that about 1 out of 2 individuals/households who exited poverty did so by transitioning out of agriculture into the rural nonfarm economy or secondary towns. Only 1 out of 7 exited poverty by migrating to the big cities, even though(More)
As biomarker discovery takes centre-stage, the role of immunohistochemistry within that process is increasing. At the same time, the number of antibodies being produced for "research use" continues to rise and it is important that antibodies to be used as biomarkers are validated for specificity and sensitivity before use. This guideline seeks to provide a(More)
Viral respiratory tract infections are known triggers of asthma exacerbations in both adults and children. The current standard of care, inhaled CS (corticosteroids) and LABAs (long-acting β2-adrenoceptor agonists), fails to prevent the loss of control that manifests as an exacerbation. In order to better understand the mechanisms underlying viral asthma(More)
Despite the availability of recently developed chemotherapy regimens, survival times for pancreatic cancer patients remain poor. These patients also respond poorly to immune checkpoint blockade therapies (anti-CTLA-4, anti-PD-L1, anti-PD-1), which suggests the presence of additional immunosuppressive mechanisms in the pancreatic tumour microenvironment(More)
The great economist Arthur Lewis emphasized the distinction between traditional agriculture and urban industries. In his view, savings and investment originate solely in the latter, while vast pools of underutilized labor can be found in the traditional sector (Lewis, 1954). In this paper, we aim at filling a gap in his analysis by constructing a model of(More)