Arthur R. Edwards

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We describe a strategy for comprehending signaling pathways that are active in lung cancer cells and that are targeted by dasatinib using chemical proteomics to identify direct interacting proteins combined with immunoaffinity purification of tyrosine-phosphorylated peptides corresponding to activated tyrosine kinases. We identified nearly 40 different(More)
A common approach towards the role of the moderator in Internet discussions is to see him as a filter. In this article I want to show that the moderator in government-initiated Internet discussions about public issues can be seen as a democratic intermediary, and that this role has the potential to enhance the quality of those discussions as forms of(More)
A conceptual framework is proposed for discussing the ICT strategies of intermediaries and their effects on democratic intermediation. The main line of reasoning is that both 'disintermediation' and 're-intermediation' have to be related to specific models of democracy and styles of citizenship. The linkage strategies of preference intermediaries, the(More)
What is the significance of ICT's for voting decisions? This chapter assesses two uses of ICT's: (1) databases of the voting records of representatives, and (2) a decision support system for party choice. It examines the information-seeking behavior of (prospective and retrospective) voters appraising either parties or individual candidates. Empirically,(More)