Arthur PH de Jong

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The strength of presynaptic terminals is very heterogeneous in the central nervous system. Even synapses formed by the same axon release different amount of vesicles during action potential firing. The rules that determine the strength of individual terminals are incompletely understood. Previous studies have shown that presynaptic strength is dependent on(More)
Synaptogenesis requires the expression and delivery of hundreds of proteins, but the transcriptional control of this process is poorly understood. Based on studies in invertebrates, the tumor suppressor gene MEN1 was suggested to be an essential transcription factor for synaptogenesis. Here, we investigated the role of menin in synaptogenesis in cultured(More)
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