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This paper considers the minimization of a convex integral functional over the positive cone of an Lp space, subject to a finite number of linear equality constraints. Such problems arise in spectral estimation, where the objective function is often entropy-like, and in constrained approximation. The Lagrangian dual problem is finite-dimensional and… (More)

- Deborah L. Clarke, Nicola H E Davis, +5 authors Richard D . May
- Clinical science
- 2014

Viral respiratory tract infections are known triggers of asthma exacerbations in both adults and children. The current standard of care, inhaled CS (corticosteroids) and LABAs (long-acting β2-adrenoceptor agonists), fails to prevent the loss of control that manifests as an exacerbation. In order to better understand the mechanisms underlying viral asthma… (More)

- Arthur Lewis
- 2002

Initial velocity studies and product inhibition patterns for purine nucleoside phosphorylase from rabbit liver were examined in order to determine the predominant catalytic mechanism for the synthetic (forward) and phosphorolytic (reverse) reactions of the enzyme. Initial velocity studies in the absence of products gave intersecting or converging linear… (More)

- Arthur Lewis
- 2002

Homogeneous guanine deaminase (guanine aminohydrolase, EC 3.5.4.3) is a single polypeptide chain of mean molecular weight of 55,000, as determined by Sephadex gel filtration and sodium dodecyl sulfate polyacrylamide disc gel electrophoresis. Irreversible inactivation was observed upon incubation with P-chloromercuribenzoate, at a concentration of 1.0 x lop4… (More)

* This is a revised version of the Inaugural Lecture of a Lecture Series that was organised at the World Bank for the Bank’s Environmentally Sustainable Development Month (April 2002). The original version served as a background paper at the United Nations’ World Summit on Sustainable Development, Johannesburg, 26 August 4 September 2002. The text was also… (More)

- William J. Howat, Arthur Lewis, +6 authors Anthony Warford
- Methods
- 2014

As biomarker discovery takes centre-stage, the role of immunohistochemistry within that process is increasing. At the same time, the number of antibodies being produced for "research use" continues to rise and it is important that antibodies to be used as biomarkers are validated for specificity and sensitivity before use. This guideline seeks to provide a… (More)

- Nadia M. Luheshi, Jane Coates-Ulrichsen, +8 authors Robert W. Wilkinson
- Oncotarget
- 2016

Despite the availability of recently developed chemotherapy regimens, survival times for pancreatic cancer patients remain poor. These patients also respond poorly to immune checkpoint blockade therapies (anti-CTLA-4, anti-PD-L1, anti-PD-1), which suggests the presence of additional immunosuppressive mechanisms in the pancreatic tumour microenvironment… (More)

- Gustav Ranis, Arthur Lewis
- 2004

Arthur Lewis’ seminal 1954 paper and its emphasis on dualism appeared at a time when neither the work of Keynes or Harrod-Domar nor the later neoclassical production function of Solow seemed relevant for developing countries. As a consequence, his model, rooted in the classical tradition, plus its many extensions, generated an extensive literature at the… (More)

- M . Borwein, Arthur Lewis, Dominikus Noll
- 1996

Maximum entropy spectral density estimation is a technique for reconstructing an unknown density function from some known measurements by maximizing a given measure of entropy of the estimate. Here we present a variety of new entropy measures which attempt to control derivative values of the densities. Our models apply among others to the inference problem… (More)

- . V . Burke, Arthur Lewis, yand M . L . OvertonzFebruary
- 2002