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The pleiotropic functions of small GTPase Rho present a challenge to its genetic analysis in multicellular organisms. We report here the use of the MARCM (mosaic analysis with a repressible cell marker) system to analyze the function of RhoA in the developing Drosophila brain. Clones of cells homozygous for null RhoA mutations were specifically labeled in(More)
Giant axonal neuropathy (GAN), an autosomal recessive disorder caused by mutations in GAN, is characterized cytopathologically by cytoskeletal abnormality. Based on its sequence, gigaxonin contains an NH2-terminal BTB domain followed by six kelch repeats, which are believed to be important for protein-protein interactions (Adams, J., R. Kelso, and L.(More)
This paper describes a methodology for designing Open Implementations-software modules that can adapt or change their internals to accommodate the needs of different clients. Analysis techniques are used for capturing domain knowledge, user requirements, and domain properties that influence the module's eventual implementation. Design techniques are used(More)
We reviewed existing and planned adaptation activities of federal, tribal, state, and local governments and the private sector in the United States (U.S.) to understand what types of adaptation activities are underway across different sectors and scales throughout the country. Primary sources of review included material officially submitted for(More)
Standardization on Shear wave ultrasound elastography (SWUE) technical settings will not only ensure that the results are accurate, but also detect any differences over time that may be attributed to true physiological changes. The present study evaluated the variations of elastic modulus of muscle and tendon using SWUE when different technical aspects were(More)
iant axonal neuropathy (GAN), an autosomal re-cessive disorder caused by mutations in GAN , is characterized cytopathologically by cytoskeletal abnormality. Based on its sequence, gigaxonin contains an NH 2-terminal BTB domain followed by six kelch repeats, which are believed to be important for protein–protein interactions Here, we report the(More)
  • Susanne Haefeli, Martina Bosi, +30 authors Cédric Philibert
  • 2004
The International Energy Agency's (" IEA ") Executive Director and Energy & Environment Division are responsible for the publication of this Information Paper (hereafter the " Paper "). The IEA makes every attempt to ensure, but does not guarantee, the accuracy and completeness of the information or the clarity of content of the Paper. Although part of the(More)
Includes an overview of the workshop the position papers. ABSTRACT This is a preview of the workshop on Aspect-Oriented Programming at ICSE 98. It includes an overview of the position papers. The workshop takes place on Monday, April the 20 th 1998. 1 STATEMENT OF WORK Mechanisms for defining and composing abstractions are essential elements of programming(More)
BACKGROUND Patients who undergo percutaneous coronary intervention (PCI) for severely calcified coronary lesions have long been known to have worse clinical and economic outcomes than patients with no or mildly calcified lesions. We sought to assess the likely cost-effectiveness of using the Diamondback 360(®) Orbital Atherectomy System (OAS) in the(More)