Arthur Lazarus

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OBJECTIVE This 52-week randomized, double-blind, flexible-dose, multicenter study evaluated the overall effectiveness (as measured by treatment discontinuation rates) of olanzapine, quetiapine, and risperidone in patients early in the course of psychotic illness. METHOD Patients were randomly assigned to treatment with olanzapine (2.5-20 mg/day),(More)
INTRODUCTION Once-daily extended release quetiapine fumarate (quetiapine XR) monotherapy was evaluated in major depressive disorder (MDD). METHOD This was an 8-week (6-week randomized-phase; 2-week drug-discontinuation/tapering phase), double-blind, parallel-group, placebo-controlled study. The primary outcome measure was Montgomery-Asberg Depression(More)
OBJECTIVE To evaluate the efficacy and tolerability of once-daily extended release quetiapine fumarate (quetiapine XR) as monotherapy treatment for major depressive disorder (MDD). METHOD This 8-week (6-week active-treatment, randomized phase; 2-week posttreatment drug-discontinuation/tapering phase), multicenter, double-blind, randomized, parallel-group,(More)
Psychoses due to thyrotoxicosis are typically affective in nature. We report on a schizophreniform psychosis in a woman with Graves' disease whose symptoms abated following subtotal thyroidectomy. Surgical thyroidectomy should be considered in thyrotoxic patients who are unresponsive to medical therapy or who manifest unremitting or life-threatening(More)
  • A Lazarus
  • The Journal of nervous and mental disease
  • 1986
A case of neuroleptic malignant syndrome unresponsive to supportive medical therapy was successfully treated by electroconvulsive therapy. Electroconvulsive therapy may offer a safe and rapidly effective intervention in cases of neuroleptic malignant syndrome complicated by high fever and severe muscular rigidity which do not improve with supportive care.
A patient with severe tardive dyskinesia developed fatal myoglobinuric renal failure. Myoglobinuria has followed other forms of extreme muscular exertion, but has not been previously reported consequent to tardive dyskinesia. Antipsychotic medication should be used to treat severe tardive dyskinesia when alternative forms of therapy are ineffective and(More)
An unusual case of Munchausen's syndrome is described in which a former microbiology technician was suspected of inoculating himself with contaminated material to produce sepsis and ingesting warfarin in the form of rat poison to cause hematuria. This combination of factitious disorders has rarely been reported. Other unusual features included a nonemergent(More)