Arthur LaPorta

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We report a procedure to detect electrical activity in cultured neurons by changes in their intrinsic optical properties. Using dark-field microscopy to detect scattered light, we observe an optical signal that is linearly proportional to the change in the membrane potential. Action potentials can be recorded without signal averaging. We use the dark-field(More)
Individual action potentials in axons can be detected in vitro using intrinsic optical signals. The principles of this detection technique are described here. The technique has been demonstrated using neuronal axons dissected from lobster. It would also be applicable to axons and active dendrites of cultured neurons with diameters somewhat larger than an(More)
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