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We describe a strategy for comprehending signaling pathways that are active in lung cancer cells and that are targeted by dasatinib using chemical proteomics to identify direct interacting proteins combined with immunoaffinity purification of tyrosine-phosphorylated peptides corresponding to activated tyrosine kinases. We identified nearly 40 different(More)
Activating mutations in the epidermal growth factor receptor (EGFR) selectively activate signal transducers and activators of transcription (STAT) and Akt survival signaling pathways important in lung cancer cell growth and survival. Many kinases, such as EGFR, rely on heat shock protein 90 (Hsp90) chaperone function for conformational maturation and proper(More)
Driver tyrosine kinase mutations are rare in sarcomas, and patterns of tyrosine phosphorylation are poorly understood. To better understand the signaling pathways active in sarcoma, we examined global tyrosine phosphorylation in sarcoma cell lines and human tumor samples. Anti-phosphotyrosine antibodies were used to purify tyrosine phosphorylated peptides,(More)
Teaching network intrusion detection, or NID (the identification of violations of a security policy in a computer network) is a challenging task, because students need to analyze many data from network logs and in real time to identify patterns of network attacks, making these activities visually tiring. This paper describes an ongoing research concerned(More)
Driver tyrosine kinase mutations are rare in sarcomas, and patterns of tyrosine phosphorylation are poorly understood. To better understand the signaling pathways active in sarcoma, we examined global tyrosine phosphorylation in sarcoma cell lines and human tumor samples. Anti-phosphotyrosine antibodies were used to purify tyrosine phosphorylated peptides,(More)
AbstrAct This chapter provides an overview of second language learning and an approach on how wireless col-laborative virtual reality can contribute to resolving important pedagogical challenges. Second language learning provides an exceptional opportunity to employ mobility and multimedia in the context of just-in-time-learning in formal learning(More)
Never has the speed of development in the area of engineering been as accelerated as it is today, as we observe the enormous and driven growth of the area of engineering. Today's tendencies require concerted new efforts in engineering education-or in other words: The importance of pedagogy in the field of engineering is growing enormously. These changes(More)
This paper presents a performance analysis of topological and geographical multicast routing algorithms for mobile wireless ad hoc networks. Flooding and On-Demand Multicast Routing Protocol (ODMRP) are simulated and compared with two novels protocols proposed: Topological Multicast Routing Protocol (ToMuRo) and Geographical Multicast Routing Protocol(More)
Small and medium-sized businesses (SMBs) in most world economies suffer from a series of intense economic pressures from local, regional and international markets. Although these problems are microeconomic to the small and medium-sized business , they are directly related to macro economic factors, particularly in the case of labor. One of the main(More)
In this paper, we present a reactive location routing algorithm with cluster-based flooding for inter-vehicle communication. We consider a motorway environment with associated high mobility and compare position-based and non-position-based routing strategies, along with a limiting function for flooding mechanisms in reactive ad-hoc protocols. The(More)