Arthur Coste

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BACKGROUND CCDC39 and CCDC40 genes have recently been implicated in primary ciliary dyskinesia (PCD) with inner dynein arm (IDA) defects and axonemal disorganisation; their contribution to the disease is, however, unknown. Aiming to delineate the CCDC39/CCDC40 mutation spectrum and associated phenotypes, this study screened a large cohort of patients with(More)
BACKGROUND Primary ciliary dyskinesia (PCD) is a rare congenital respiratory disorder characterized by abnormal ciliary motility leading to chronic airway infections. Qualitative evaluation of ciliary beat pattern based on digital high-speed videomicroscopy analysis has been proposed in the diagnosis process of PCD. Although this evaluation is easy in(More)
Objectives Muco-ciliary clearance is the airway first mechanism of defence against environmental attacks such as microorganisms or pollution. Cilia motility impairment can be either of genetic (primary ciliary dyskinesia) or acquired origin (environmental attacks), entailing chronic diseases. It is of interest for practitioners to evaluate cilia beating(More)
Objective Ciliary dysfunctions may have deleterious consequences on mucociliary clearance. We propose a new approach based on coupling the isolated ciliary beat pattern and the global efficiency of ciliary beat on human ciliated cells. Methods Ciliated cells issued from nasal brushing (controls and primary ciliary dyskinesia patients) were recorded by(More)
BACKGROUND Epithelial damage and modifications of cell differentiation are frequent in airway diseases with chronic inflammation, in which transforming growth factor-beta1 (TGF-beta1) plays an important role. The aim of this study was to evaluate the differentiation of human nasal epithelial cells (HNEC) after wound healing and the potential effects of(More)
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