Arthur Chernoff

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BACKGROUND Identifying the predictors of co-morbidity improvement after gastric bypass surgery (Roux-en-Y gastric bypass) might give insight into disease pathophysiology. METHODS We performed an observational study of 949 patients undergoing primary RYGB from 2005 to 2010. Multivariate mixed models were used to determine the predictors of change in(More)
In vitro, IL-10 inhibits T cell proliferation and LPS-induced monocyte production of IL-1, TNF-alpha, IL-6, and IL-8. We studied the safety and immunomodulatory effects of IL-10 administration in humans. Seventeen healthy volunteers received a single i.v. bolus injection of either human IL-10 (1, 10, or 25 micrograms/kg) or placebo. Routine safety(More)
Four platelet proteins are secreted by platelets during the release reaction: platelet factor 4 (PF4).1 $-thromboglobulin ( 9TG). platelet-derived growth factor (PDGF). and fibrinogen. The characteristics of release of these proteins and 14Cserotonin (14C-5HT) were studied and compared with secretion of acid hydrolases as described by others.’ Distinct(More)
BACKGROUND There has been limited research examining the mechanisms and epidemiology of sexual dysfunction in the morbidly obese. Our objectives were to measure sexual function in the morbidly obese man before and after substantial weight loss induced by gastric bypass surgery. STUDY DESIGN All male patients in undergoing gastric bypass completed the(More)
Platelet alpha-granules contain a factor that stimulates the proliferation of arterial smooth muscle cells and may play a role in atherogenesis. We have studied the role of arachidonic acid in mediating the release of the platelet-derived growth factor (PDGF) from human platelets. PDGF was assayed by stimulating of [(3)H]thymidine incorporation into DNA of(More)
OBJECTIVE To study hypoglycemia in hospitalized patients without diabetes and to assess the role of underlying illness in th development of hypoglycemia and its association with outcome. METHODS We undertook a retrospective review of medical records at a university-affiliated tertiary care teaching hospital to identify adult patients without diabetes,(More)
Growth factor activity, as determined by the stimulation of [3H]thymidine incorporation into the DNA of quiescent 3T3 cells in culture, was found in lysates of guinea pig platelets and megakaryocytes. Quantitative dilution studies demonstrated that, of the cells present in the guinea pig bone marrow, only the megakaryocyte possessed quantitatively(More)