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The teratogenic effects of the coadministration of alcohol (ethanol) and cocaine to pregnant C57BL/6J mice were investigated using an acute treatment model on gestation day 10 (GD10). The day of mating was designated as GD1. Pregnant mice were assigned to treatment groups generated from a 3(0, 4, 6 g/kg alcohol) x 3 (0, 40, 60 mg/kg cocaine) factorial(More)
PURPOSE Variable-angle volar locked constructs for distal radius fractures are a recent treatment addition. This study sought to biomechanically evaluate a variable-angle volar locking plate as compared with a fixed-angle construct. METHODS We created 2 different AO-C3 osteotomies in fourth-generation synthetic composite distal radiuses and labeled them(More)
The teratogenic effects of the coadministration of alcohol and cocaine on gestation days 14-17 were investigated using an acute exposure model. Pregnant C57BL/6J mice were assigned randomly to treatment groups generated from a 2 (0 or 6 g/kg alcohol) x 2 (0 or 60 mg/kg cocaine) x 4 (day of treatment) factorial design. An untreated control group was also(More)
A gas chromatographic-mass spectrometric method is described for the determination of cocaine and ethylcocaine (cocaethylene) from mouse plasma microsamples (50 microliters). [2H3]Cocaine and [2H5]ethylcocaine served as internal standards, analytical separations were performed on a (5% phenyl)methylpolysiloxane capillary column, and detection was by(More)
The teratogenic effects of cocaine and ethanol were investigated using an acute treatment model of C57BL/6J mice treated on gestation day 15 (GD15) with evaluation on GD17. Females were intubated once with a subteratogenic dose of ethanol (0 or 4 g/kg) and injected subcutaneously twice, 1 h apart, with equal doses of cocaine HCl (0 or 60 mg/kg), for a final(More)
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