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Atonal is a Drosophila proneural protein required for the proper formation of the R8 photoreceptor cell, the founding photoreceptor cell in the developing retina. Proper expression and refinement of the Atonal protein is essential for the proper formation of the Drosophila adult eye. In vertebrates, expression of transcription factors orthologous to(More)
OBJECTIVE To compare the long term efficacy and adverse events of dual blockade of the renin-angiotensin system with monotherapy. DESIGN Systematic review and meta-analysis. DATA SOURCES PubMed, Embase, and the Cochrane central register of controlled trials, January 1990 to August 2012. STUDY SELECTION Randomised controlled trials comparing dual(More)
2 About Monitor Deloitte and Monitor Inclusive Markets: Monitor Deloitte is one of the global brands of Deloitte Touche Tohmatsu Limited, a UK private company limited by guarantee which renders management consulting services, advising corporations, governments and international development agencies worldwide. Monitor Inclusive Markets (MIM), a unit of(More)
Hepatocellular carcinoma (HCC) is the most common form of liver cancer (~80%), and it is one of the few cancer types with rising incidence in the United States. This highly invasive cancer is very difficult to detect until its later stages, resulting in limited treatment options and low survival rates. There is a dearth of knowledge regarding the mechanisms(More)
Breast cancer resistance protein (Bcrp/Abcg2) localized at the blood-brain barrier (BBB) limits permeability into the brain of many xenobiotics, including pharmacological agents. Peroxisome proliferator-activated receptor α (Pparα), a ligand-activated transcription factor, primarily involved in lipid metabolism, has been shown to regulate the functional(More)
— We discuss the application of biogeography-based optimization (BBO) to invariant set approximation. BBO is a recently developed evolutionary algorithm (EA) that is motivated by biogeography, which is the study and science of the geographical migration of biological species. Invariant sets are sets in the state space of a dynamic system such that if the(More)
We present hardware testing of an evolutionary algorithm known as biogeography-based optimization (BBO) and extend it to distributed learning. BBO is an evolutionary algorithm based on the theory of biogeography, which describes how nature geographically distributes organisms. We introduce a new BBO algorithm that does not use a centralized computer, and(More)
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