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PURPOSE This study was designed to quantify the temporary loop ileostomy-related morbidity in patients with colorectal cancer and contrast the morbidity rates after ileostomy closure before, during, and after the start of adjuvant therapy. METHODS Between 1997 and 2004, 120 patients with colorectal carcinoma underwent colorectal resection and creation of(More)
BACKGROUND A prospective clinical study was performed to assess the accuracy of procalcitonin in 70 patients with elective colorectal or aortal surgery and to compare it with inflammatory mediators. Also the early prediction of complications and the outcome of these patients was taken into account. METHODS Laboratory variables and cytokine determination(More)
BACKGROUND Functional results after rectal resection with straight coloanal anastomosis are poor. While most functional aspects are improved with coloanal J pouch anastomosis, it is still unclear whether this translates into better quality of life. The aim of this trial was to investigate health-related quality of life as a primary endpoint in patients(More)
OBJECTIVE Roux-en-Y reconstruction with and without jejunal pouch was compared in a randomized controlled trial to identify the optimal reconstruction procedure in terms of quality of life. BACKGROUND DATA Randomized trials comparing techniques of reconstruction after total gastrectomy have shown controversial results. METHODS One hundred and(More)
BACKGROUND Among the most prominent metabolic alterations in cancer cells are the increase in glucose consumption and the conversion of glucose to lactic acid via the reduction of pyruvate even in the presence of oxygen. This phenomenon, known as aerobic glycolysis or the Warburg effect, may provide a rationale for therapeutic strategies that inhibit tumour(More)
In a first clinical trial with the apoptosis-inducing human antibody SC-1 eight patients with poorly differentiated stomach adenocarcinoma of diffuse-type received 20 or 30 mg of purified SC-1 antibody intravenously, followed 24 or 48 h later by gastrectomy and lymphadenectomy. In seven cases a significant induction of apoptotic activity was measured in(More)
OBJECTIVE Four different braided absorbable surgical materials (Dexon, Dexon II Bicolor, Vicryl and Polysorb) 2/0 USP, which basically share the same indications, were studied in vitro and in vivo with regard to their physical properties as well as tissue compatibility and surgical handling. Analyzing the results the authors tried to determine the most(More)
BACKGROUND To assess the accuracy of procalcitonin as a measure of severity in patients with septic abdominal illnesses and the sepsis syndrome, to compare measurements with those of other inflammatory mediators, and to predict outcome. METHODS We carried out a prospective clinical study from 246 patients with infective or septic episodes confirmed at(More)
Growth factors are mediators with essential importance for undisturbed repair process after wounding. The coordinated concert of these substances is necessary for healing with complete restoration of function and morphology. These complex mechanisms are disturbed during secondary and delayed repair. Local and systemic application of these growth factors(More)
BACKGROUND The appropriate management of the pancreatic remnant following distal pancreatic resection remains a clinically relevant problem. We carried out a retrospective analysis which focused on this issue and compared the two favored techniques of suture and staple closure. PATIENTS AND METHODS Forty-six patients underwent distal pancreatectomy(More)