Arnold M. Michelson

Learn More
Free radicals have long been well known by physicists but have only interested biologists since 1969 when Fridovich showed that O2 was produced during an enzymatic oxidation. O2 and related radicals are highly toxic. This implies that, in all aerobic cells, mechanisms exist which inactivate free radicals as soon as they are produced by oxidative metabolism.(More)
Liposomal-encapsulated superoxide dismutase was clinically applied to patient showing an increase in neutrophil active oxygen generation, and those with diseases such as severe rheumatoid arthritis (RA), Crohn's disease and progressive systemic sclerosis (PSS) in which presence of a plasmatic clastogenic factor has been demonstrated. Liposomal SOD injection(More)
The activity of glutathione peroxidase (GSH-Px) as well as the activities of other antioxidative enzymes: CuZn superoxide dismutase (CuZn SOD), catalase (CAT), glutathione reductase (GR) in erythrocytes, as well as the activity of plasma glutathione transferase (GST), and the plasma content of vitamins E and C were evaluated in 35 sporadic amyotrophic(More)
After they gave a classification of the different circumstances under which the infantile autism can exist, the authors expose the data of their researches on the intermediate metabolism of oxygen of those children. Superoxyde dismutase I and glutathion peroxydase activities seem to be abnormal in the erythrocytes whereas only superoxyde dismutase I(More)
The effect of NO treatment in vitro on structural and functional alterations of Cu/Zn, Mn, and Fe type of SODs was studied. Significant difference in response to NO of Cu/ZnSOD compared to the Mn and Fe types was demonstrated. Cu/ZnSOD was shown to be stable with respect to NO: even on prolonged exposure, NO produced negligible effect on its structure and(More)
The serum of patients with systemic lupus erymathosus contains a chromosome-breaking agent of low molecular weight, which produces chromosomal breakage and rearrangement in lymphocyte cultures of healthy donors. This breakage factor is probably produced by or released from the cells of patients, since lymphocyte extracts and cocultivation of patients'(More)