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The alpha and beta forms of the pregnancy-associated protein, SP1 which have been previously identified in late pregnancy serum were found to be also present in the placenta. The alpha form was somewhat more difficult to extract, requiring the use of detergents in the extracting buffer. The two variants can be separated by ion exchange chromatography or by(More)
Pregnancy-associated plasma protein A (PAPP-A) was measured by rocket immunoelectrophoresis in 272 patients at 34 weeks of pregnancy and within 48 hours before delivery. The values obtained have been compared to maternal parameters (age, weight, weight gain, blood group, rhesus factor, and parity) and to fetal parameters (sex, weight, Apgar score, rhesus(More)
The plasma concentration of PAPP-A has been measured in 84 patients with pre-eclamptic toxaemia within 24 hours of their first admission to hospital. There were 51 patients who suffered from mild pre-eclampsia (late pregnancy hypertension without albuminuria). The PAPP-A values in these patients did not differ significantly from the normal value for the(More)
Progesterone concentrations in cord artery and vein and in retroplacental and maternal blood were measured in 43 women delivered by caesarean section. The cord vein concentration was consistently higher than the cord artery concentration. The two were correlated but neither was related to the concentration in retroplacental blood. It was concluded that(More)
The plasma concentration of pregnancy-associated plasma protein A (PAPP-A) was measured in 34 women during the last 10 weeks of pregnancy. From 30 to 36 weeks the concentration of this protein increased steadily. Thereafter the concentration of PAPP-A rose more steeply, the highest amounts being found in early labour. The concentration of PAPP-A in(More)
The plasma concentrations of Schwangerschaftsprotein 1 (SP1) and human chorionic gonadotrophin (hCG) were measured in 22 women before and after conception. In these pregnancies ovulation occurred spontaneously in seven subjects, or followed treatment with either clomiphene citrate (6 subjects), or human menopausal gonadotrophin (hMG) and hCG (6 subjects).(More)