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It is widely accepted that interleukin-1beta (IL-1beta), a cytokine produced not only by immune cells but also by glial cells and certain neurons influences brain functions during infectious and inflammatory processes. It is still unclear, however, whether IL-1 production is triggered under nonpathological conditions during activation of a discrete neuronal(More)
A family is described which displays a typical picture of autosomal-dominant inherited myopathia distalis tarda hereditaria, which is very rare outside Sweden. Three subjects still living who are carriers show, as probable heterozygotes, a very homotypical clinical picture but with distinct participation of the muscles of the proximal extremities and the(More)
Cross-sections and angular distributions for hadronic and lepton pair final states in e + e − collisions at a centre-of-mass energy near 189 GeV, measured with the OPAL detector at LEP, are presented and compared with the predictions of the Standard Model. The results are used to measure the energy dependence of the electromagnetic coupling constant α em ,(More)
In the cat caudate nucleus the same nine types of synapses are found as in putamen and fundus striati. The three parts of the striatum in the strict sense do not differ in the morphological differentiation of synapse types but only in their quantitative distribution. One-third of all synapses in the caudate nucleus are axo-spinous type IV synapses with a(More)
A combined Golgi/electron microscopic technique was used to investigate tne fine structure and synaptology of Golgi-stained spiny neurons in the caudate nucleus of the cat. In order to study the termination sites of cortical afferents on Golgi-stained spiny neurons, cortical fibres were caused to degenerate by making extensive cortical lesions 3 days prior(More)
Hyperbaric oxygen treatment has been suggested as able to reduce hypoxia induced neuronal damage. The aim of the study was to compare the impact of different reoxygenation strategies on early metabolical (purine nucleotide content determined by HPLC) and morphological changes (index of cell injury after celestine blue/acid fuchsin staining) of hypoxically(More)
In a first series of experiments, the morphological changes of corticoencephalic cells by ischaemia were determined by staining with celestine blue-acid fuchsin in order to classify cells as intact, dark basophilic (supposedly reversibly injured) and preacidophilic or acidophilic (profoundly injured). Hypoxia and glucose-deprivation (in vitro ischaemia)(More)
In Wilson's disease a disturbed glucose metabolism especially in striatal and cerebellar areas has been reported. This is correlated with the severity of extrapyramidal motor symptoms (EPS). These findings are only based on a small number of patients. Up to now it is unknown whether EPS are caused by various patterns of disturbed basal ganglia glucose(More)