Learn More
There is currently no calibration available for the whole human mtDNA genome, incorporating both coding and control regions. Furthermore, as several authors have pointed out recently, linear molecular clocks that incorporate selectable characters are in any case problematic. We here confirm a modest effect of purifying selection on the mtDNA coding region(More)
Clinical outcome and relevance of genetic and epidemiological factors were evaluated in 161 patients with idiopathic Parkinson's disease (PD) with regard to onset symptoms [tremor (T) vs non-tremor (NT)], to clinical classification into tremor-dominant (TD), alkineto-rigid (AR), and equivalent (EQ) subtypes, and to disease onset before the 45th year of age(More)
In this context, the term 'marker' needs to be explained. Occasionally, in the course of the millennia , mutations may occur in the DNA of an organism , such as a human or a seed of grain, and these mutations are passed down to the descendants. If these descendants remain united by a common characteristic such as a language, a certain geographic area, or a(More)
  • 1