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The MAP kinase JNK‐1 of Caenorhabditis elegans: Location, activation, and influences over temperature‐dependent insulin‐like signaling, stress responses, and fitness
The mitogen‐activated protein kinase (MAPK) pathways and insulin‐like signaling play pivotal roles in cellular stress response. Using an anti‐phospho‐SAPK/JNK antibody and a daf‐16::GFP‐basedExpand
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Identification of Human Cathepsin G As a Functional Target of Boswellic Acids from the Anti-Inflammatory Remedy Frankincense1
Frankincense preparations, used in folk medicine to cure inflammatory diseases, showed anti-inflammatory effectiveness in animal models and clinical trials. Boswellic acids (BAs) constitute majorExpand
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Boswellic acids from frankincense inhibit lipopolysaccharide functionality through direct molecular interference.
Lipophilic extracts of gum resins of Boswellia species (BSE) are used in folk medicine to treat various inflammatory disorders and infections. The molecular background of the beneficialExpand
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Boswellic acids target the human immune system-modulating antimicrobial peptide LL-37.
The antimicrobial peptide LL-37 is the sole member of the human cathelicidin family with immune system-modulating properties and roles in autoimmune disease development. Small molecules able toExpand
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Triterpene Acids from Frankincense and Semi-Synthetic Derivatives That Inhibit 5-Lipoxygenase and Cathepsin G
Age-related diseases, such as osteoarthritis, Alzheimer’s disease, diabetes, and cardiovascular disease, are often associated with chronic unresolved inflammation. Neutrophils play central roles inExpand
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Identification of LL-37 as a Molecular Target for Boswellic Acids
Gum resin extracts of Boswellia serrata have been traditionally applied in folk medicine for the treatment of various inflammatory diseases. Analyses of these extracts identified a group ofExpand
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Interference of alpha-alkyl-substituted pirinixic acid derivatives with neutrophil functions and signalling pathways.
Pirinixic acid (Wy-14,643) is an agonist of the peroxisome proliferator-activated receptor (PPAR) subtype alpha exhibiting beneficial effects in various inflammation-related processes in a slow,Expand
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