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Normal-appearing white matter has been shown via diffusion tensor imaging to be affected in tuberous sclerosis complex. Under the hypothesis that some systems might be differentially affected, including the visual pathways and systems of social cognition, diffusion properties of various regions of white matter were compared. For 10 patients and 6(More)
In this paper, a novel method for EEG to MRI registration is proposed. Initial registration is achieved by extracting and matching symmetry planes of MRI and EEG data, followed by iterative registration based on minimizing a cost function. Comparison of the intensity distributions of the whole MR image and MRI voxels around a head surface point yields(More)
The software requirements for computer-aided navigation tools in image-guided therapy become increasingly complex as a result of new imaging and tracking hardware, novel application areas and regulatory restrictions. The objective of this work was to develop a new software framework to meet the needs of emerging image-guided procedures and therapies that(More)
The disruption of normal function and connectivity of neural circuits is common across many diseases and disorders of the brain. This disruptive effect can be studied and analyzed using the brain's complex functional and structural connectivity network. Complex network measures from the field of graph theory have been used for this purpose in the(More)
We present a new method to compute the convex hull of a structure. Based on a morphological definition of the convex hull as the intersection of all half-planes containing a structure, it can be computed by projecting all pixels to a line that is defining a certain half-plane. We use our method to detect stenoses and atherosclerotic plaques in grey scale(More)
Recent advances in functional MRI (fMRI) and diffusion tensor imaging (DTI) enable the delineation of eloquent cortical areas and the underlying white matter tracts that connect them. Information from each of these modalities can dramatically impact the decision to operate, but the use of pre-surgical data for on-line, intraoperative decision making is(More)
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