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- Arne C. Müller, Alexander Bockmayr
- Bioinformatics
- 2013

MOTIVATION
Flux variability analysis (FVA) is an important tool to further analyse the results obtained by flux balance analysis (FBA) on genome-scale metabolic networks. For many constraint-based models, FVA identifies unboundedness of the optimal flux space. This reveals that optimal flux solutions with net flux through internal biochemical loops are… (More)

- Arne C Müller, Alexander Bockmayr
- Journal of mathematical biology
- 2014

The huge number of elementary flux modes in genome-scale metabolic networks makes analysis based on elementary flux modes intrinsically difficult. However, it has been shown that the elementary flux modes with optimal yield often contain highly redundant information. The set of optimal-yield elementary flux modes can be compressed using modules. Up to now,… (More)

- Arne C. Müller, Frank J. Bruggeman, Brett G. Olivier, Leen Stougie
- RECOMB
- 2014

Flux balance analysis (FBA) is one of the most often applied methods on genome-scale metabolic networks. Although FBA uniquely determines the optimal yield, the pathway that achieves this is usually not unique. The analysis of the optimal-yield flux space has been an open challenge. Flux variability analysis is only capturing some properties of the flux… (More)

- Christina Gunkel, Alexander Stepper, Arne C. Müller, Christine H. Müller
- Machine Vision and Applications
- 2011

A package based on the free software R is presented which allows the automatic detection of micro cracks and corresponding statistical analysis of crack quantities. It uses a shortest path algorithm to detect micro cracks in situations where the cracks are surrounded by plastic deformations and where a discrimination between cracks and plastic deformations… (More)

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