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The InnoMed PredTox consortium was formed to evaluate whether conventional preclinical safety assessment can be significantly enhanced by incorporation of molecular profiling ("omics") technologies. In short-term toxicological studies in rats, transcriptomics, proteomics and metabolomics data were collected and analyzed in relation to routine clinical(More)
The European InnoMed-PredTox project was a collaborative effort between 15 pharmaceutical companies, 2 small and mid-sized enterprises, and 3 universities with the goal of delivering deeper insights into the molecular mechanisms of kidney and liver toxicity and to identify mechanism-linked diagnostic or prognostic safety biomarker candidates by combining(More)
Lymphatic filarial infection in humans is associated with a strong skewing of the immune response towards the TH2 arm, with prominent interleukin 4-producing cells and elevated levels of immunoglobulin G4 (IgG4) and IgE antibodies in peripheral blood. To determine how such a generalized TH2 imbalance governs responses to individual parasite antigens, the(More)
The kidney is one of the main targets of drug toxicity, but early detection of renal damage is often difficult. As part of the InnoMed PredTox project, a collaborative effort aimed at assessing the value of combining omics technologies with conventional toxicology methods for improved preclinical safety assessment, we evaluated the performance of a panel of(More)
Gentamicin is an aminoglycoside antibiotic, which induces renal tubular necrosis in rats. In the context of the European InnoMed PredTox project, transcriptomic and proteomic studies were performed to provide new insights into the molecular mechanisms of gentamicin-induced nephrotoxicity. Male Wistar rats were treated with 25 and 75 mg/kg/day subcutaneously(More)
We investigate the possibilities of searching for non-standard CP violation in pp → t ¯ tX at multiple TeV collision energies. A general kinematic analysis of the underlying partonic production processes gg → t ¯ t and q ¯ q → t ¯ t in terms of their density matrices is given. We evaluate the CP-violating parts of these matrices in two-Higgs doublet(More)
We discuss rescattering effects that can be measured in e + e − annihilation to three jets through a single gauge boson, by using triple product (" event handedness ") correlations of the Z (γ *) polarization with jet momenta. The gauge boson polarization may be produced either by polarized beams or through the natural polarization (left-right asymmetry) of(More)