Arnaud Alvès

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N Engl J Med 2003;348:727-34. Copyright © 2003 Massachusetts Medical Society. n increase in tissue corticosteroid levels during acute illness is an important protective response. Many diseases and their treatments interfere with the normal corticosteroid response to illness and thus induce tissue corticosteroid insufficiency. In this article, we review the(More)
BACKGROUND Researchers have suggested that antibiotics could cure acute appendicitis. We assessed the efficacy of amoxicillin plus clavulanic acid by comparison with emergency appendicectomy for treatment of patients with uncomplicated acute appendicitis. METHODS In this open-label, non-inferiority, randomised trial, adult patients (aged 18-68 years) with(More)
BACKGROUND The purpose of this study was to determine the natural history of anastomotic leakage after elective colorectal resection and supraperitoneal anastomosis without temporary stoma. STUDY DESIGN Medical records from 1990 to 1997 were studied; 655 consecutive patients underwent colonic or rectal resection (without stoma). Patients were divided into(More)
Paradoxically, reactive oxygen species (ROS) can promote normal cellular proliferation and carcinogenesis, and can also induce apoptosis of tumor cells. In this report, we study the contribution of ROS to various cellular signals depending on the nature and the level of ROS produced. In nontransformed NIH 3T3 cells, ROS are at low levels and originate from(More)
In a double-blind, parallel group trial, 78 subjects with social phobia received moclobemide (a new reversible inhibitor of monoamine oxidase A) phenelzine, or placebo. After eight weeks, both active drugs-phenelzine somewhat more than moclobemide--were clinically and statistically significantly more effective than placebo, as assessed by rating scales.(More)
The aim of this study was to determine by univariate and multivariate analyses the factors associated with clinically significant anastomotic leakage (AL) after large bowel resection. From 1990 to 1997 a series of 707 patients underwent colonic or rectal resection (without a stoma). Patients were divided into two groups: those with clinical anastomotic(More)
PURPOSE This study was designed to assess predictive factors of postoperative intra-abdominal septic complication in a homogenous group of patients undergoing ileocecal resection for Crohn's disease. METHODS From 1984 to 2004, 161 consecutive patients with Crohn's disease (81 males; mean age, 33 +/- 10 years) underwent, as a first operation, an elective(More)
HYPOTHESIS Better knowledge of independent risk factors might decrease mortality and morbidity rates following colorectal surgery. DESIGN Prospective multicenter study. INTERVENTIONS From June to September 2002, consecutive patients undergoing open or laparoscopic surgery (electively or on an emergent basis) for colorectal cancers or diverticular(More)
BACKGROUND Resection of the rectal primary neoplasm with synchronous liver metastases (LM) is warranted, because this is the only strategy with curative potential. Combined resection remains controversial because of the risk of morbidity and necessity of a curative abdominal approach to warrant liver resection. Laparoscopic colorectal resection may be(More)
PURPOSE Tobacco smoking is associated with a higher risk of developing colorectal cancer. This study was designed to assess the role of smoking in early onset of colorectal pathology. METHODS This was a prospective cross-sectional study of 997 patients with colorectal cancer. Age of colorectal cancer diagnosis was studied in two groups of patients, i.e.,(More)