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Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease.
It is demonstrated here that deficiency of recipient-derived IL-22 increased acute GVHD tissue damage and mortality, that ISCs were eliminated during GV HD, and thatISCs as well as their downstream progenitors expressed the IL- 22 receptor. Expand
Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation
GVHD is associated with significant shifts in the composition of the intestinal microbiota in human and mouse models; manipulating the microbiota can alter the severity of GVHD in mice.
Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells
It is demonstrated that targeting PI3Kγ with a selective inhibitor can reshape the tumour immune microenvironment and promote cytotoxic-T-cell-mediated tumour regression without targeting cancer cells directly. Expand
Interleukin-22 Drives Endogenous Thymic Regeneration in Mice
Mechanisms of endogenous thymic repair are revealed and offer innovative regenerative strategies for improving immune competence. Expand
Nrf2 regulates haematopoietic stem cell function
It is demonstrated that nuclear factor erythroid 2-related factor 2 (Nfe2l2, or Nrf2), well established as a global regulator of the oxidative stress response, plays a regulatory role in several aspects of HSC homeostasis and a previously unrecognized link between NRF2 and CXCR4 is identified, contributing, at least partially, to the maintenance of H SC function. Expand
Global Spread of SARS-CoV-2 Subtype with Spike Protein Mutation D614G is Shaped by Human Genomic Variations that Regulate Expression of TMPRSS2 and MX1 Genes
SARS-CoV-2, particularly the 614G subtype, has spread more easily and with higher frequency to Europe and North America where the delC allele regulating expression of TMPRSS2 and MX1 host proteins is common, but not to East Asia where this allele is rare. Expand
NOD2 regulates hematopoietic cell function during graft-versus-host disease
It is found that proliferation and activation of donor T cells was enhanced in NOD-deficient allo-BMT recipients, suggesting that NOD2 plays a role in the regulation of host antigen-presenting cells (APCs). Expand
Cardiovascular disease risk factors in Asian Indian population: A systematic review.
Current understanding of the epidemiology of cardiovascular disease, particularly, coronary heart disease (CHD), stroke and related risk factors in Asian Indian population is provided. Expand
Association of food patterns, central obesity measures and metabolic risk factors for coronary heart disease (CHD) in middle aged Bengalee Hindu men, Calcutta, India.
Conicity index (CI) was found to be the most consistent in explaining metabolic variables of CHD, and significant negative association of chicken and fish consumption with central obesity measures indicates the beneficial effect of both these items in this population. Expand
Protective effect of aqueous garlic extract against lead-induced hepatic injury in rats.
Results indicate that AGE has the potential to ameliorate lead-induced hepatic injury due to oxidative stress in rats and the protective effects may be due to the antioxidant properties of AGE and may have future therapeutic relevance. Expand