#### Filter Results:

- Full text PDF available (12)

#### Publication Year

2009

2017

- This year (2)
- Last 5 years (17)
- Last 10 years (19)

#### Publication Type

#### Co-author

#### Journals and Conferences

#### Key Phrases

Learn More

We perform an error analysis for numerical approximation methods of continuous time Markov chain models commonly found in the chemistry and biochemistry literature. The motivation for the analysis is to be able to compare the accuracy of different approximation methods and, specifically, Euler tau-leaping and midpoint tau-leaping. We perform our analysis… (More)

- Michael Klann, Arnab Ganguly, Heinz Koeppl
- Bioinformatics
- 2012

MOTIVATION
Cellular signal transduction involves spatial-temporal dynamics and often stochastic effects due to the low particle abundance of some molecular species. Others can, however, be of high abundances. Such a system can be simulated either with the spatial Gillespie/Stochastic Simulation Algorithm (SSA) or Brownian/Smoluchowski dynamics if space and… (More)

- Alina A Alexeenko, Arnab Ganguly, Steven L Nail
- Journal of pharmaceutical sciences
- 2009

Analysis of water vapor flows encountered in pharmaceutical freeze-drying systems, laboratory-scale and industrial, is presented based on the computational fluid dynamics (CFD) techniques. The flows under continuum gas conditions are analyzed using the solution of the Navier-Stokes equations whereas the rarefied flow solutions are obtained by the direct… (More)

- Arnab Ganguly, Steven L Nail, Alina Alexeenko
- Journal of pharmaceutical sciences
- 2013

The study is aimed at quantifying the relative contribution of key heat transfer modes in lyophilization. Measurements of vial heat transfer rates in a laboratory-scale freeze-dryer were performed using pure water, which was partially sublimed under various conditions. The separation distance between the shelf and the vial was systematically varied, and… (More)

- Arnab Ganguly, Derya Altintan, Heinz Koeppl
- Multiscale Modeling & Simulation
- 2015

Biochemical reactions can happen on different time scales and also the abundance of species in these reactions can be very different from each other. Classical approaches, such as deterministic or stochastic approach fail to account for or to exploit this multi-scale nature, respectively. In this paper, we propose a jumpdiffusion approximation for… (More)

- Tatjana Petrov, Arnab Ganguly, Heinz Koeppl
- Electr. Notes Theor. Comput. Sci.
- 2012

In this paper, we discuss a method for decomposition, abstraction and reconstruction of the stochastic semantics of rule-based systems with conserved number of agents. Abstraction is induced by counting fragments instead of the species, which are the standard entities of information in molecular signaling. The rule-set can be decomposed to smaller… (More)

- Pooja Sane, Nikhil Varma, Arnab Ganguly, Michael Pikal, Alina Alexeenko, Robin H. Bogner
- AAPS PharmSciTech
- 2016

Product temperature during the primary drying step of freeze-drying is controlled by a set point chamber pressure and shelf temperature. However, recent computational modeling suggests a possible variation in local chamber pressure. The current work presents an experimental verification of the local chamber pressure gradients in a lab-scale freeze-dryer.… (More)

- Tobias Sutter, Arnab Ganguly, Heinz Koeppl
- Journal of Machine Learning Research
- 2016

We consider a hidden Markov model, where the signal process, given by a diffusion, is only indirectly observed through some noisy measurements. The article develops a variational method for approximating the hidden states of the signal process given the full set of observations. This, in particular, leads to systematic approximations of the smoothing… (More)

- Arnab Ganguly, Tatjana Petrov, Heinz Koeppl
- Journal of mathematical biology
- 2014

We consider a continuous-time Markov chain (CTMC) whose state space is partitioned into aggregates, and each aggregate is assigned a probability measure. A sufficient condition for defining a CTMC over the aggregates is presented as a variant of weak lumpability, which also characterizes that the measure over the original process can be recovered from that… (More)

- Arnab Ganguly, Alina A Alexeenko, Steven G Schultz, Sherry G Kim
- European journal of pharmaceutics and…
- 2013

A physics-based model for the sublimation-transport-condensation processes occurring in pharmaceutical freeze-drying by coupling product attributes and equipment capabilities into a unified simulation framework is presented. The system-level model is used to determine the effect of operating conditions such as shelf temperature, chamber pressure, and the… (More)