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A novel X-linked combined immunodeficiency disease was found in five living males in an extended family in the United States. The age of the affected males ranged from 2.5 to 34 yr. The most prominent clinical abnormalities were a paucity of lymphoid tissue; recurrent sinusitis, otitis media, bronchitis, and pneumonia; severe varicella; and chronic(More)
Physiologic delays in production of immune factors occur in mammals including Homo sapiens. This finding is counter to a basic tenet of biologic evolution, because such delays increase the risk of infections. The disadvantage is, however, offset by defense factors in milk of the species in whom the developmental delay occurs. Reciprocal relationships(More)
In addition to well-recognized antimicrobial substances, a growing body of evidence has accrued during the last decade regarding the presence and function of immunomodulatory and anti-inflammatory factors present in human milk and their role in protecting the mature newborn as well as the premature infant against infections. In addition, it is now(More)
The H-2 region of mouse chromosome 17 is known to include one or more genes that affect susceptibility to cortisone-induced cleft palate. We have now studied congenic strains that possess crossovers in the interval between H-2S and H-2D and have observed significant differences in susceptibility among recombinants that had been believed to possess the same(More)
Congenital malformations now represent the largest single cause of mortality in the infant of the diabetic mother. The mechanism by which diabetes exerts its teratogenic effects is not known. This study evaluated whether arachidonic acid might be involved, a possibility raised by the role of arachidonic acid in palatal elevation and fusion, processes(More)
Sixty-nine whites (38 men and 31 women) aged 17 to 88 years and 48 blacks (19 men and 29 women) aged 17 to 61 years were studied. Each person walked in desert heat for 1 hour at a rate requiring 40% of aerobic capacity. Observations were recorded on their rectal temperature (Tre), skin temperature (Tsk), heart rate (HR), blood pressure, and sweat rate (SR).(More)