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BACKGROUND Intense and rapidly changing mood states are a major feature of borderline personality disorder (BPD); however, there have only been a few studies investigating affective processing in BPD, and in particular no neurofunctional correlates of abnormal emotional processing have been identified so far. METHODS Six female BPD patients without(More)
Findings from cerebral magnetic resonance imaging (MRI) studies in schizophrenia indicating temporal lobe involvement have been inconsistent and controversial. In a prospective study, we quantified the volumes of temporal lobe structures in 20 male patients with first episode schizophrenia (FES; mean+/-S.D.=27.4+/-4. 8 years) and 20 healthy age-matched male(More)
The popular recreational drug ecstasy (3,4-methylenedioxymethamphetamine=MDMA and related congeners) is neurotoxic upon central serotonergic systems in animal studies. So far, the most convincing evidence for neurotoxicity-related functional deficits in humans derives from neurocognitive studies demonstrating dose-related long-term learning and memory(More)
The occurrence of aphasia or neglect was related to anatomo-structural (CT/MRI), functional [regional cerebral blood flow (rCBF)] and pathogenetic features [duration of middle cerebral artery (MCA) occlusion and degree of cortical leptomeningeal anastomoses] in 57 cases (26 with and 31 without aphasia or neglect) with strictly subcortical infarcts of one(More)
Measurements of the total convoluted surface area of cortex buried in the temporoparietal transition of the Sylvian fissure were performed using "three-dimensional" magnetic resonance morphometry in 10 randomly selected human cadaver brains. The measurements comprised the planum temporale, which covers the superior temporal gyrus posterior to Heschl's first(More)
We performed functional magnetic resonance imaging (MRI) in professional piano players and control subjects during an overtrained complex finger movement task using a blood oxygenation level dependent echo-planar gradient echo sequence. Activation clusters were seen in primary motor cortex, supplementary motor area, premotor cortex and superior parietal(More)
The popular recreational drug 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) has well-recognized neurotoxic effects upon central serotonergic systems in animal studies. In humans, the use of MDMA has been linked to cognitive problems, particularly to deficits in long-term memory and learning. Recent studies with proton magnetic resonance spectroscopy (1H(More)
Modulation of the blood estrogen level as it occurs during the menstrual cycle has a strong influence on both neuropsychological and neurophysiological parameters. One of currently preferred hypotheses is that the menstrual cycle hormones modulate functional hemispheric lateralization. We examined six male and six female subjects by functional magnetic(More)
A method is described for the imaging and planimetric measurement of the planum temporale (PT) using computer reformations from three-dimensional fast low angle shot magnetic resonance (MR) data. The procedure allows the determination of size and left-right asymmetry of this area on the posterior supratemporal surface, which has been assumed by previous(More)
BACKGROUND AND PURPOSE One major limitation of current functional MR (fMR) imaging is its inability to clarify the relationship between sites of cortical neuronal activation, small parenchymal venules that are in close proximity to these sites, and large draining veins distant from the active parenchyma. We propose to use gradient-echo blood oxygenation(More)