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JNK Activation Turns on LPS- and Gram-Negative Bacteria-Induced NADPH Oxidase-Dependent Suicidal NETosis
Neutrophils cast neutrophil extracellular traps (NETs) to ensnare microbial pathogens. Nevertheless, the molecular rheostats that regulate NETosis in response to bacteria are not clearly established.… Expand
The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling
Linking protein misfolding and innate immunity Multiple innate immune sensors undergo rapid assembly into large complexes known as signalosomes. This is an essential step during cellular responses to… Expand
Hypertonic Saline Suppresses NADPH Oxidase-Dependent Neutrophil Extracellular Trap Formation and Promotes Apoptosis
- Ajantha Nadesalingam, Jacky H. K. Chen, Armin Farahvash, M. Khan
- Chemistry, Medicine
- Front. Immunol.
- 8 March 2018
Tonicity of saline (NaCl) is important in regulating cellular functions and homeostasis. Hypertonic saline is administered to treat many inflammatory diseases, including cystic fibrosis. Excess… Expand
Isoginkgetin, a Natural Biflavonoid Proteasome Inhibitor, Sensitizes Cancer Cells to Apoptosis via Disruption of Lysosomal Homeostasis and Impaired Protein Clearance
- Jessica Tsalikis, Mena Abdel-Nour, +4 authors S. Girardin
- Biology, Medicine
- Molecular and Cellular Biology
- 25 March 2019
Protein degradation pathways are critical for maintaining proper protein dynamics within the cell, and considerable efforts have been made toward the development of therapeutics targeting these… Expand
Severe optic neuropathy as the presenting sign of leptomeningeal carcinomatosis from pancreatic cancer.
Apraclonidine for the pharmacologic confirmation of acute Horner syndrome
- Michael T B Nguyen, Armin Farahvash, Angela Zhang, J. Micieli
- Journal of the Neurological Sciences
- 14 October 2020
Apraclonidine is the most widely used pharmacologic agent to confirm Horner syndrome. It is a strong α-2 and a weak α-1 adrenergic agonist and reversal of anisocoria is considered a positive test.… Expand
Neuro-Ophthalmological Manifestations of Obstructive Sleep Apnea: Current Perspectives
Abstract Obstructive sleep apnea (OSA) is a disease of obstructed airways during sleep that significantly impacts the quality of life and increases the risk of various systemic diseases. OSA has been… Expand
Sinonasal Chondrosarcoma Presenting With Isolated Severe Vision Loss.
- Michael T B Nguyen, Armin Farahvash, +4 authors J. Micieli
- Journal of neuro-ophthalmology : the official…
- 27 October 2020
A 24-year-old man presented with a 2-month history of progressive, painless vision loss in the right eye, with no history of headache, nasal congestion, rhinorrhea, or epistaxis. His visual acuity… Expand